THE NATURAL HISTORY OF OSTEOPENIA IN GIRLS WITH RETT SYNDROME

RETT 综合征女孩骨质减少的自然史

• 批准号: 7374953
• 负责人: KATHLEEN J MOTIL
• 金额: $ 2.92万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7374953
• 关键词: NATURAL; HISTORY; OSTEOPENIA; GIRLS; RETT

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Osteopenia and its attendant fracture risk complicate the clinical course of girls and women with Rett syndrome (RTT). The prevalence and etiology of osteopenia in RTT is unknown. The purpose of this study is to characterize the natural history of osteopenia in girls and women with RTT relative to normative data and to determine if associations between bone demineralization and dietary, inflammatory, endocrine, or physical factors are present in these individuals. We will measure BMC using duel energy x-ray absorptiometry in 60 RTT girls and women. Bone fracture prevalence will be documented and ambulatory status will be scored. Anthropometric measurements, dietary recall, blood and urine sampling, and hand radiographs will be obtained to determine relations between BMC and regional muscle mass, dietary nutrient intakes, markers of bone formation and degradation, hormonal factors related to calcium and vitamin D metabolism, and markers of inflammation. The results of this study will provide benchmark information about the prevalence of osteopenia and its associated risk factors in RTT girls and women. Ultimately, the information obtained from this research should lead to the development of therapeutic and preventative strategies that promote the health and well-being of all girls and women affect with RTT.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。骨量减少及其伴随的骨折风险使Rett综合征（RTT）女孩和妇女的临床病程复杂化。RTT中骨质减少的患病率和病因尚不清楚。本研究的目的是描述RTT女孩和女性骨量减少的自然史，并确定这些个体中骨脱矿与饮食、炎症、内分泌或身体因素之间是否存在相关性。我们将使用双能X线吸收法测量60名RTT女孩和妇女的BMC。将记录骨折患病率，并对非卧床状态进行评分。将获得人体测量、饮食回忆、血液和尿液采样以及手部X光片，以确定BMC与局部肌肉质量、饮食营养摄入量、骨形成和降解标志物、与钙和维生素D代谢相关的激素因子以及炎症标志物之间的关系。这项研究的结果将提供基准信息的患病率骨量减少及其相关的风险因素在RTT的女孩和妇女。最终，从这项研究中获得的信息应该导致制定治疗和预防战略，促进所有受RTT影响的女孩和妇女的健康和福祉。