MALTASE-GLUCOAMYLASE: REGULATOR OF STARCH DIGESTION

麦芽糖酶-葡糖淀粉酶：淀粉消化的调节剂

• 批准号: 7374928
• 负责人: BUFORD L NICHOLS
• 金额: $ 1.95万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7374928
• 关键词: MALTASE; GLUCOAMYLASE; REGULATOR; STARCH; DIGESTION

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Chronic recurrent abdominal pain (RAP) in children, a common, but perplexing problem that frequently becomes irritable bowel syndrome in young adults. It appears that many cases of RAP related to carbohydrate maldigestion and development a screening non-radioactive breath test will be helpful in management of RAP. This GCRC protocol supports development of a non-radioactive starch breath test and provides the basis for a subsequent and broader National Institute of Health proposal. If successfully calibrated, the 13C-breath-test could replace the more expensive endoscopic procedures currently in use. It could bring more specificity to the diagnosis of recurrent abdominal pain (RAP) in children.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中得到体现。列出的机构是中心的机构，不一定是研究者的机构。儿童慢性复发性腹痛 (RAP) 是一种常见但令人困惑的问题，在年轻人中经常演变成肠易激综合症。看来许多 RAP 病例与碳水化合物消化不良有关，开发筛查性非放射性呼吸测试将有助于 RAP 的管理。该 GCRC 协议支持非放射性淀粉呼气测试的开发，并为后续更广泛的国家卫生研究院提案提供了基础。如果校准成功，13C 呼吸测试可以取代目前使用的更昂贵的内窥镜程序。它可以为儿童复发性腹痛（RAP）的诊断带来更多特异性。