LOW CARBOHYDRATE ON FASTING AND POST FAT LOAD LIPOPROTEINS OF DIABETICS

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。中度高甘油三酯血症（空腹甘油三酯300 - 800毫克/分升）的糖尿病患者将饮食改为高单不饱和脂肪/低碳水化合物（HFLC）饮食比改为低脂肪/高碳水化合物（LFHC）饮食更能降低空腹甘油三酯（TG）。目的1是确定糖尿病合并中度高甘油三酯血症患者接受低脂饮食或高脂饮食治疗后空腹TG的变化。中度高甘油三酯血症的糖尿病患者在标准脂肪餐后，将饮食改为HFLC饮食比改为LFHC饮食更能降低餐后TG和富甘油三酯脂蛋白（TRL）。目的2是确定中度高甘油三酯血症糖尿病患者接受低脂饮食或高脂饮食治疗后，标准脂肪餐后餐后TG和TRL的变化。大约14名受试者，男性或女性，18 - 75岁，2型糖尿病患者，空腹甘油三酯300 - 800 mg/dl将被随机化。在筛选访问之后，受试者最初将被随机分配到LFHC或HFLC体重维持饮食。LFHC饮食将包括30%的脂肪（10%的单不饱和脂肪，10%的饱和脂肪，10%的多不饱和脂肪），55%的CHO和15%的蛋白质。HFLC饮食将是等热量的，提供40%的CHO， 45%的脂肪（25%的单不饱和脂肪，10%的饱和脂肪，10%的多不饱和脂肪）和15%的蛋白质。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Changing the diet to a high monounsaturated fat/low carbohydrate (HFLC) diet in diabetics with moderate hypertriglyceridemia (fasting triglycerides 300 800 mg/dl) will decrease the fasting triglycerides (TG) more than changing to a low fat/high carbohydrate (LFHC) diet. Aim 1 is to determine the change in fasting TG in diabetics with moderate hypertriglyceridemia treated with a LFHC or a HFLC diet. Changing the diet to a HFLC diet in diabetics with moderate hypertriglyceridemia will decrease postprandial TG and triglyceride rich lipoproteins (TRL) after a standard fat meal more than changing to a LFHC diet. Aim 2 is to determine the change in postprandial TG and TRL after a standard fat meal in diabetics with moderate hypertriglyceridemia treated with a LFHC diet or a HFLC diet. Approximately 14 subjects, male or female 18 75 years of age, with type 2 diabetes and fasting triglycerides 300 - 800 mg/dl will be randomized. Following the screening visit, subjects will be initially randomized to either LFHC or HFLC weight maintenance diets. The LFHC diet will consist of 30% fat (10% monounsaturated, 10% saturated, 10% polyunsaturated), 55% CHO and 15 % protein. The HFLC diet will be isocaloric and provide 40% CHO, 45% fat (25% monounsaturated, 10% saturated, 10% polyunsaturated fat) and 15% protein.