CRP & HEMODYNAMICALLY SIGNIFICANT ASYMPTOMC EXTRACRANIAL CAROTID ARTERY ATHEROSC

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。血清炎症标志物，如C-反应蛋白，已被确定为外周动脉疾病的预测因子。随着新出现的证据表明炎症标志物与血管疾病有关，再加上关于非冠状动脉疾病，特别是无症状疾病的数据相对匮乏，这项研究旨在评估无症状颈动脉疾病背景下血清炎症标志物升高的存在。这将为未来的纵向研究奠定基础，以评估血清标记物的效用，以确定那些可能面临经历无症状疾病进展的风险的患者。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Serum markers of inflammation such as C-reactive protein have been identified as predictors of peripheral arterial disease. With emerging evidence associating inflammatory markers with vascular disease, coupled with the relative paucity of data regarding non-coronary, and particularly asymptomatic disease, this study is designed to assess the presence of elevated serum markers of inflammation in the setting of asymptomatic carotid artery disease. This will lay the groundwork for future longitudinal studies to assess the utility of serum markers to identify those patients that may be at risk to experience asymptomatic progression of disease.