ACTIVATED CHARCOAL AS AN AID IN TREATING CROHN'S DISEASE

活性炭有助于治疗克罗恩病

• 批准号: 7377132
• 负责人: KEN KENINGSBERG
• 金额: $ 8.57万
• 依托单位: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7377132
• 关键词: ACTIVATED; CHARCOAL; AID; TREATING; CROHN

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The study we are engaged in is based on laboratory data we have accumulated showing that oral charcoal given prophylactically to mice decreases tumor necrosis factor (TNF) levels and increases survival in endotoxemia. Crohn's Disease is characterized by recurrences accompanied by increased TNF levels in blood and stool while subsidences are coupled with lowered TNF in blood and stool. Since anti-TNF antibodies have been found to be helpful in treating Crohn's Disease, we are currently involved in determing whether oral charcoal will decrease TNF and improve symptoms in patients suffering from Crohn's Disease.

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。我们从事的这项研究是基于我们积累的实验室数据，表明预防性给予小鼠口服木炭可以降低肿瘤坏死因子(TNF)水平，并增加内毒素血症的存活率。克罗恩病的特点是复发，并伴有血液和粪便中肿瘤坏死因子水平的升高，而消退伴随着血液和粪便中肿瘤坏死因子的降低。由于抗肿瘤坏死因子抗体已被发现对治疗克罗恩病有帮助，我们目前正在研究口服木炭是否会降低肿瘤坏死因子并改善克罗恩病患者的症状。