ACTIVATED CHARCOAL AS AN AID IN TREATING CROHN'S DISEASE

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。我们从事的这项研究是基于我们积累的实验室数据，这些数据表明，口服活性炭可降低小鼠的肿瘤坏死因子（TNF）水平，并增加内毒素血症的存活率。 克罗恩病的特征在于复发伴随血液和粪便中TNF水平的增加，而消退伴随血液和粪便中TNF水平的降低。由于抗TNF抗体已被发现有助于治疗克罗恩病，我们目前正在确定口服活性炭是否会降低TNF并改善克罗恩病患者的症状。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The study we are engaged in is based on laboratory data we have accumulated showing that oral charcoal given prophylactically to mice decreases tumor necrosis factor (TNF) levels and increases survival in endotoxemia. Crohn's Disease is characterized by recurrences accompanied by increased TNF levels in blood and stool while subsidences are coupled with lowered TNF in blood and stool. Since anti-TNF antibodies have been found to be helpful in treating Crohn's Disease, we are currently involved in determing whether oral charcoal will decrease TNF and improve symptoms in patients suffering from Crohn's Disease.