NON-ANDRENERGIC MECHANISMS OF CUTANEOUS VASOCONSTRICTION IN YOUNG & AGED SKIN

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。当一个人暴露在寒冷的环境中时，身体通过收缩皮肤中的血管来保存热量。这减少了温暖的血液通过寒冷的流动。然而，衰老会削弱皮肤血管收缩的能力。这会导致老年人在寒冷的时候皮肤血流量更高，使他们更容易热量流失。这个项目的目的是研究局部皮肤降温引起血管收缩的机制。该项目还将探索衰老如何影响这些机制。这项研究的目的是调查皮肤中的一种特定的酶，Rho激酶和活性氧物种(ROS)是否有助于局部皮肤降温引起的皮肤血管收缩，以及这些作用如何随年龄的变化而变化。我们假设：1)ROS和Rho激酶都促进了年轻人和老年人的血管收缩，2)ROS和Rho Kinase在老年人的血管收缩中起到了更大的作用，这是衰老过程的结果。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. When a person is exposed to a cold environment, the body conserves heat by constricting blood vessels in the skin. This reduces the flow of warm blood through cold. However, aging impairs the ability of the skin's blood vessels to constrict. This causes older individuals to have a higher skin blood flow in the cold and makes them more vulnerable to heat loss. The purpose of this project is to examine the mechanisms responsible for vasoconstriction induced by local cooling of the skin. The project will also explore how aging affects those mechanisms. The goal of this study is to investigate whether a particular enzyme in the skin, Rho kinase, and reactive oxygen species (ROS) contribute to skin vasoconstriction in response to local skin cooling and how those contributions may change with aging. We hypothesize that 1) both ROS and Rho kinase contribute to vasoconstriction in young and older people, and 2) ROS and Rho kinase contribute to a greater portion of vasoconstriction in older people as a result of the aging process.