COLORECTAL CANCER

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。本协议描述并支持我们最近资助的美国癌症协会针对贫困和服务不足人群的定向研究补助金：“hMSH2和hMLH1介导的非洲裔美国人结直肠癌”，该研究旨在分析DNA错配修复基因对非洲裔美国人结直肠癌发病率的贡献。本议定书还描述了对ACS资助项目中非洲裔美国人研究的直接和合乎逻辑的扩展。这一扩展旨在包括所有患结直肠癌风险增加的个人和家庭，无论其国籍或种族。到目前为止，错配修复基因的文献主要集中在高度选择的，广泛的谱系，以多个受影响个体为特征。基于人群的错配修复基因相关的结直肠癌和其他相关恶性肿瘤的分析仍未报道。本议定书将促进结直肠癌风险增加的家庭和个人的鉴定和分子遗传学特征，而不受高度选择的谱系的限制；一个新颖的贡献。这项工作将阐明错配修复基因对结直肠癌总体发病率的贡献。它还将促进未来努力确定与结直肠癌易感性相关的新遗传因素，以及影响对化学预防、初级治疗和自然史反应的因素。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This protocol describes and supports our recently funded American Cancer Society Targeted Research Directed at Poor and Underserved Populations Grant entitled: "hMSH2 and hMLH1 Mediated Colorectal Cancer Among African-Americans" a study designed to analyze the contribution of the DNA mismatch repair genes to colorectal cancer incidence among African American. This Protocol also describes a direct and logical extension of the research described for the African-American population in our ACS funded project. This extension is designed to include all individuals and families at increased risk of developing colorectal cancer regardless of national or ethnic origin. The mismatch repair gene literature to date has predominantly focused on highly selected, extensive pedigrees characterized by multiple affected individuals. A population based analysis of mismatch repair gene associated colorectal and other related malignancies remains unreported. This Protocol will facilitate the identification and molecular genetic characterization of families and individuals at increased risk of colorectal cancer without restriction to highly selected pedigrees; a novel contribution. This effort will clarify the contribution of the mismatch repair genes to overall colorectal cancer incidence. It will also facilitate future efforts to identify novel genetic factors associated with colorectal cancer predisposition as well as factors that influence response to chemoprevention, primary treatment and natural history.