COLORECTAL CANCER

结直肠癌

• 批准号: 7375463
• 负责人: THOMAS J WEBER
• 金额: $ 1.36万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7375463
• 关键词: COLORECTAL; CANCER

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This protocol describes and supports our recently funded American Cancer Society Targeted Research Directed at Poor and Underserved Populations Grant entitled: "hMSH2 and hMLH1 Mediated Colorectal Cancer Among African-Americans" a study designed to analyze the contribution of the DNA mismatch repair genes to colorectal cancer incidence among African American. This Protocol also describes a direct and logical extension of the research described for the African-American population in our ACS funded project. This extension is designed to include all individuals and families at increased risk of developing colorectal cancer regardless of national or ethnic origin. The mismatch repair gene literature to date has predominantly focused on highly selected, extensive pedigrees characterized by multiple affected individuals. A population based analysis of mismatch repair gene associated colorectal and other related malignancies remains unreported. This Protocol will facilitate the identification and molecular genetic characterization of families and individuals at increased risk of colorectal cancer without restriction to highly selected pedigrees; a novel contribution. This effort will clarify the contribution of the mismatch repair genes to overall colorectal cancer incidence. It will also facilitate future efforts to identify novel genetic factors associated with colorectal cancer predisposition as well as factors that influence response to chemoprevention, primary treatment and natural history.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。该方案描述并支持我们最近资助的美国癌症协会针对贫困和服务不足人群的有针对性的研究，该研究题为：“hMSH 2和hMLH 1介导的非裔美国人结直肠癌”，该研究旨在分析DNA错配修复基因对非裔美国人结直肠癌发病率的贡献。该协议还描述了一个直接的和合乎逻辑的扩展研究所描述的非洲裔美国人在我们的ACS资助的项目。这一扩展旨在包括所有患结直肠癌风险增加的个人和家庭，无论其民族或种族。错配修复基因的文献主要集中在高度选择，广泛的家系特征是多个受影响的个人。基于人群的错配修复基因相关结直肠癌和其他相关恶性肿瘤的分析尚未报道。该方案将促进结直肠癌风险增加的家庭和个人的鉴定和分子遗传学特征，而不限于高度选择的谱系;一个新的贡献。这项工作将阐明错配修复基因对整体结直肠癌发病率的贡献。它还将促进未来的努力，以确定与结直肠癌易感性相关的新的遗传因素，以及影响对化学预防，主要治疗和自然史的反应的因素。