ADIPOSE TISSUE DISTR ADIPOKINES & APPETITE REG HORMONES /CUSHING'S DISEASE

脂肪组织分布脂肪因子

• 批准号: 7380591
• 负责人: ELIZA Brevoort GEER
• 金额: $ 0.27万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-17 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7380591
• 关键词: adiponectin; adipose tissue; appetite; body composition; fasting; fats; ghrelin; leptin; role

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cushing's disease is associated with profound body composition changes. These changes include an increase in central versus peripheral fat deposition. After surgical treatment of Cushing's, over time the body composition changes normalize. These changes in body composition are felt to be due to direct actions of cortisol on fat tissue, but new research has shown that other hormones may be involved as well. Adipokines (leptin and adiponectin) as well as appetite hormones (ghrelin and PYY) seem to play a role in appetite and obesity. This study proposes to investigate the role of these hormones in the body composition changes seen in Cushing's. We plan to follow 10 Cushing's patients over time before and after surgical treatment. There will be one pre-operative and two post-operative visits, the first post-operative visit while the patient has been on a stable dose of steroids for at least 6 months and the second while the patient has been off steroids for at least 6 months. We will measure fasting leptin and adiponectin as well as glucose, insulin, PYY, and ghrelin before and at 30, 60, 90, 120, and 180 minutes after a test meal. Subjects will complete a questionnaire before and after the test meal to measure levels of hunger and satiety. We will also recruit 10 control patients to undergo these hormone tests during one study visit. In the Cushing's patients, we will investigate adipose distribution by whole-body MRI, to correlate the changes in hormone levels with body composition changes that occur with treatment of Cushing's disease. Hypothesis 1: Compared to BMI-matched controls, patients with active Cushing's disease will have low fasting ghrelin levels that fail to display normal suppression after a meal, which will resolve after surgical cure.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中得到体现。列出的机构是中心的机构，不一定是研究者的机构。库欣病与身体成分的深刻变化有关。这些变化包括中央脂肪沉积相对于外周脂肪沉积的增加。库欣病的手术治疗后，随着时间的推移，身体成分的变化会恢复正常。人们认为身体成分的这些变化是由于皮质醇对脂肪组织的直接作用造成的，但新的研究表明其他激素也可能参与其中。脂肪因子（瘦素和脂联素）以及食欲激素（生长素释放肽和 PYY）似乎在食欲和肥胖中发挥着作用。这项研究旨在调查这些激素在库欣氏病身体成分变化中的作用。我们计划在手术治疗前后对 10 名库欣病患者进行长期随访。将进行一次术前访视和两次术后访视，第一次术后访视是在患者使用稳定剂量的类固醇至少 6 个月时进行的，第二次术后访视是在患者已停用类固醇至少 6 个月时进行的。我们将在测试餐前和测试餐后 30、60、90、120 和 180 分钟测量空腹瘦素和脂联素以及葡萄糖、胰岛素、PYY 和生长素释放肽。受试者将在测试餐前后填写一份调查问卷，以测量饥饿和饱腹感的程度。我们还将招募 10 名对照患者在一次研究访视期间接受这些激素测试。在库欣病患者中，我们将通过全身 MRI 检查脂肪分布，将激素水平的变化与库欣病治疗过程中发生的身体成分变化联系起来。 假设 1：与 BMI 匹配的对照组相比，患有活动性库欣病的患者空腹胃饥饿素水平较低，餐后胃饥饿素水平无法表现出正常抑制，但手术治愈后会缓解。