BRADYKININ AND BLOOD PRESSURE RESPONSE TO RAMIPRIL

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。本研究的目的是找出ACE抑制剂是如何降低PAI-1的。我们认为，ACE抑制剂可能通过增加体内一种名为一氧化氮的化学物质来降低PAI-1。为此，我们将测量血管紧张素转换酶抑制剂雷米普利、增加一氧化氮的膳食补充剂L精氨酸以及静脉注射降低一氧化氮的药物L对血液中凝血因子的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to find out how ACE inhibitors lower PAI-1. We believe that ACE inhibitors may lower PAI-1 by increasing a chemical in the body called nitric oxide. For this reason, we will measure the effect of an ACE inhibitor, ramipril; a dietary supplement that increases nitric oxide, L-arginine; and an intravenous drug that decreases nitric oxide, L-NAME, on clotting factors in the blood.