BRADYKININ AND BLOOD PRESSURE RESPONSE TO RAMIPRIL

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。本研究的目的是了解ACE抑制剂如何降低PAI-1。我们认为ACE抑制剂可能通过增加体内一种叫做一氧化氮的化学物质来降低PAI-1。因此，我们将测量一种ACE抑制剂雷米普利的效果；一种能增加一氧化氮和l -精氨酸的膳食补充剂；以及一种静脉注射药物，可以降低血液中凝血因子中的一氧化氮（L-NAME）。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to find out how ACE inhibitors lower PAI-1. We believe that ACE inhibitors may lower PAI-1 by increasing a chemical in the body called nitric oxide. For this reason, we will measure the effect of an ACE inhibitor, ramipril; a dietary supplement that increases nitric oxide, L-arginine; and an intravenous drug that decreases nitric oxide, L-NAME, on clotting factors in the blood.