KAINIC ACID DERIVATIVES

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Dr. Choony will be developing an independent research program in the use of steric buttresses to make kainic acid. Kainic acid and its derivatives are potent GABA-mimetics, showing bioactivity as neuroexcitatory agents, insecticides, and antihelminthics. Kainic acid derivatives act on both glutaminergic and GABA synapses. Neuronal cell death following injection of kainoids has been proposed as an important model for the neuronal cell loss observed in senile dementia.