Advacing Competitive Biomedical Research in Puerto Rico

描述（由申请人提供）：波多黎各大学（UPR）在此提议建立波多黎各促进卓越生物医学研究联盟（PRAABRE）。本提案响应并符合邀请IDeA生物医学研究卓越网络申请的RFA号RR-03-010。这是我们之前创建BRIN-PR网络的授权号P20 RR-16470的竞争性续期申请。波多黎各卓越生物医学研究联盟（PRAABRE）提案的主要目标是：1)在三个被认为对提高波多黎各生物医学和行为研究能力至关重要的具体研究领域，加强和加强联邦的科学基础设施和研究竞争力；2)提高生产力、竞争力和人力资源数量，以吸引这些研究领域的知名研究人员；3)促进有才能的初级研究者和资优学生的研究技能发展。PRAABRE指导委员会在所有参与机构协商一致后选定了需要加强和加强的科学领域，分别是神经科学、药物设计和给药以及分子医学。这些目标将通过创建和建立(a)行政核心，(b)生物信息学核心，(c)研究核心和(d)三个主题科学领域的外展核心来实现。行政核心将向研究网络提供行政和后勤支助。设在普遍定期审议的高性能计算设施（HPCf）内的生物信息学核心将为三个专题研究集群内的研究人员提供技术专长和数据分析工具。PRAABRE的研究核心将支持三个项目：DNA测序和多位点基因分型设施、upr -蛋白质组学设施和获取生物医学电子科学信息学（ABESI）项目。外展核心将创建支持初级研究人员和学生（研究生和本科生）的项目，以及为研究人员集群（神经科学、分子医学和药物设计与开发）内的研究人员提供其他专业发展机会，并为高中教师和学生提供沉浸式研究体验项目。最后，PRAABRE将在波多黎各的五个主要本科院校主持11个研究子项目。

DESCRIPTION (provided by applicant): The University of Puerto Rico (UPR) proposes here the creation of the Puerto Rico Alliance for the Advancement of Biomedical Research Excellence (PRAABRE). This proposal is in response to and compliant with RFA number RR-03-010 that invited applications for IDeA Networks of Biomedical Research Excellence. This is a competitive renewal application for our previous grant number P20 RR-16470 that created the BRIN-PR network. The main goals of the Puerto Rico Alliance for Biomedical Research Excellence (PRAABRE) proposal are: 1) to enhance and strengthen the scientific infrastructure and research competitiveness of the Commonwealth in three specific research areas deemed to be key to advance Puerto Rico's biomedical and behavioral research capacity; 2) to elevate the productivity, competitiveness, and number of human resources needed to attract established investigators in those research areas; and 3) to promote the development of research skills of talented junior investigators and gifted students. The scientific areas to be enhanced and strengthen were selected by the PRAABRE Steering Committee after consensus of all participating institutions, and these are Neuroscience, Drug Design and Delivery, and Molecular Medicine. These goals will be achieved by creating and establishing (a) an Administrative Core, (b) a Bioinformatics Core, (c) a Research Core, and (d) an Outreach Core on three thematic scientific areas. The Administrative Core will provide administrative and logistical support to the research networks. The Bioinformatics Core, housed at the High Performance Computing facility (HPCf) of UPR, will provide access to technical expertise and data analysis tools for the researchers within the three thematic research clusters. The Research Core of PRAABRE will support three initiatives: the DNA Sequencing and Multilocus Genotyping Facility, the UPR-Proteomics Facility, and the Access to Biomedical Electronic Scientific lnformatics (ABESI) project. The Outreach Core will create programs for support of junior researchers and students (graduate and undergraduate) as well as other Professional Development opportunities to investigators within the Researcher Clusters (Neuroscience, Molecular Medicine and Drug Design and Development), and an immersive research experience program for high school teachers and students. Finally, PRAABRE will host 11 research subprojects in five primarily undergraduate institutions in Puerto Rico.