U DE COBRE: DESIGN OF HIERARCHICAL RECOGNITION MOTIFS, ADMIN CORE

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。描述概述：Jain （PI）特拉华大学的卓越生物医学研究中心（COBRE）旨在开发控制大分子功能的结构和识别基元，并对生物材料的设计有用。这些包括小分子到蛋白质到中尺度组装之间的原子水平的相互作用。设计范例正在开发用于研究小分子-蛋白质相互作用，膜环境中的蛋白质组装，人工糖蛋白支架的构建以显示多价识别基序，以及制备结构和功能响应环境线索的肽基生物材料。人们正在寻求合成方法来制备非天然氨基酸，以便将其掺入蛋白质中以赋予其独特的结构和功能。目前正在执行五个项目，以结合基础研究和应用研究的组成部分。所有这些项目都需要关于结构主题相互作用的详细信息。这些基序的范围从特征大分子表面、结构域和支架到特定氨基酸侧链残基的功能显著性。重要的是，在每个单独项目中建立的设计原则可以应用于所有项目，以增强当前的设计策略，并进一步了解生物分子识别。所有项目均由化学与生物化学系（DCB）和材料科学与工程系（MSEG）助理教授个人指导。一般来说，项目1、3、5和6（与Polenova博士合作的新项目）属于结构生物学领域，项目2和项目4属于材料生物工程领域。项目3通过开发新的合成方法来制备非天然氨基酸，从而获得新的蛋白质结构和功能特征，从而补充了这两个一般领域。重要的是，拟议中的中心将有助于将新成立的材料科学与工程系和化学与生物化学系的有机部门整合到大学内与生物医学相关的研究方向中。第七个大分子计算化学项目将于2006年9月启动，桑迪普·帕特尔博士最近被聘用，克利福德·罗宾逊博士离职。此外，该中心将有力地补充美国国立卫生研究院（NIH）发起的蛋白质结构倡议（PSI），以及校园和周边机构的其他生物医学研究工作。作为COBRE的一部分，将提供的核心设施将加强目前在校园内建立的设施，并有助于加强特拉华大学的所有生物医学研究工作。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. DESCRIPTION Overview: Jain (PI) This Center of Biomedical Research Excellence (COBRE) at the UD aims at developing structural and recognition motifs that control functions of macromolecules and are useful for design of biomaterials. These encompass atomic-level interactions among small molecules to proteins to mesoscale assemblies. Design paradigms are being developed for the study of small molecule-protein interactions, protein assembly in membrane environments, the construction of artificial glycoprotein scaffolds to display multivalent recognition motifs, and the preparation of peptide-based biomaterials whose structures and functions are responsive to environmental cues. Synthetic methods are being pursued to prepare non-natural amino acids for incorporation into proteins to impart unique structure and function. Five projects are being carried out to incorporate both fundamental and applied research components. All of these projects require detailed information about the interplay of structural motifs. These motifs range from characteristic macromolecular surfaces, domains, and scaffolds to the functionally significant of specific amino acid side chain residues. Importantly, design principles established within each individual project can be applied across all of the projects to enhance current design strategies and further the general understanding of biomolecular recognition. All the projects are under the individual supervision of Assistant Professors in the Department of Chemistry and Biochemistry (DCB) and the Department of Materials Science and Engineering (MSEG). Broadly speaking, projects 1, 3 5 and 6 (new project with Dr. Polenova) are in the area of structural biology, and 2 and 4 are in bioengineering through materials. Project 3 complements these two general areas by developing novel synthetic methodology for the preparation of non-natural amino acids that will elicit new protein structural and functional features. Importantly, the proposed Center will serve to integrate the newly established Materials Science and Engineering Department and the Organic division of the Chemistry and Biochemistry Department into biomedical-related research directives within the University. A seventh project on Computational Chemistry of Macromolecules will be initiated in September 2006 with the recent hire of Dr. Sandeep Patel and the departure of Dr. Clifford Robinson. In addition, this Center will strongly complement not only the Protein Structure Initiative (PSI) launched by the National Institutes of Health (NIH), but also other biomedical research efforts on campus and surrounding institutions. Core facilities to be provided, as part of this COBRE will enhance those currently being established on campus and serve to strengthen all of the biomedical research efforts at the UD.