Transcription Factors in Cancer

癌症中的转录因子

• 批准号: 7110385
• 负责人: Richard M. Niles
• 金额: $ 177.54万
• 依托单位: MARSHALL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-23 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7110385
• 关键词: clinical research; neoplasm /cancer; transcription factor

DESCRIPTION (provided by applicant): Marshall University in the final stages of the development of the Edwards Cancer Center. Through the generosity of the Edwards family, funds are being used to construct a cancer center building and to establish an endowment. The new Cancer Building is currently being constructed and will be primarily a diagnostic and treatment facility. In light of these developments we are establishing a Cancer Research Center (CRC) that will complement and interdigitate with the clinical component of the Edwards Cancer Center. As part of this CRC we are proposing a COBRE entitled "Transcription Factors in Cancer" The COBRE consists of four projects and three cores. Project 1: "Beta catenin function and retinoic acid in melanoma", Beverly, Delidow, Principal Investigator will build on preliminary findings that retinoic acd reduces nuclear content and function of beta-catenin in melanoma to explore the consequences of this multifunctional protein in progression of human melanoma. Project 2: "Retinoids, NF-kB and Mn-SOD in Neuroblastoma", Kelley Kiningham, PI. will explore the hypothesis that Mn-SOD is required for retinoid-induced differentiation and that reactive oxygen species are involved in signaling. Project 3 "Sap, a potential zebrafish oncogene", Maiyon Park, Principal Investigator investigates the exciting finding that overexpression of sap in zebrafish embryos leads to tumor formation and will determine if a human oncogene counterpart is present is some human tumors. Project 4: "The role of Ski/Sno in testicular cancer", Laura Richardson, PI, deals with overexpression and function of this transcription factor in testicular cancer. These projects are supported by Administrative, Imaging and Genomics Cores. All projects deal with retinoids or its signaling pathway in a least a portion of their research. Thus there will be a great deal of interaction regarding common assays and reagents. This critical mass of investigators working on a common scientific theme with multiple interactions, supported by strong cores provides a unique opportunity for both career development of COBRE investigators and development of a nationally competitive research center.

描述（由申请人提供）： 马歇尔大学爱德华兹癌症中心发展的最后阶段。通过爱德华兹家庭的慷慨，资金被用来建造一个癌症中心大楼和建立一个捐赠。新的癌症大楼目前正在建设中，主要是一个诊断和治疗设施。鉴于这些发展，我们正在建立一个癌症研究中心（CRC），它将与爱德华兹癌症中心的临床组成部分相辅相成。作为CRC的一部分，我们提出了一个名为“癌症转录因子”的COBRE。COBRE由四个项目和三个核心组成。项目一：“黑色素瘤中的β-连环蛋白功能和视黄酸”，Beverly，Delidow，主要研究者将建立在视黄酸减少黑色素瘤中β-连环蛋白的核含量和功能的初步发现的基础上，以探索这种多功能蛋白在人类黑色素瘤进展中的后果。项目2：“神经母细胞瘤中的维甲酸、NF-kB和Mn-SOD”，Kelley Kiningham，PI。将探讨Mn-SOD是维甲酸诱导分化所需的假设，活性氧参与信号传导。项目3“Sap，一种潜在的斑马鱼癌基因”，Maiyon Park，首席研究员研究了令人兴奋的发现，即斑马鱼胚胎中sap的过度表达导致肿瘤形成，并将确定是否存在人类癌基因对应物是一些人类肿瘤。项目四：“Ski/Sno在睾丸癌中的作用”，Laura Richardson，PI，涉及睾丸癌中该转录因子的过表达和功能。这些项目得到了行政、成像和基因组学核心的支持。所有项目都涉及类维生素A或其信号通路的至少一部分研究。因此，关于常见测定和试剂将存在大量相互作用。这一临界质量的研究人员致力于一个共同的科学主题，具有多种互动，由强大的核心支持，为COBRE研究人员的职业发展和具有全国竞争力的研究中心的发展提供了独特的机会。