Transcription Factors in Cancer

癌症中的转录因子

• 批准号: 7110385
• 负责人: Richard M. Niles
• 金额: $ 177.54万
• 依托单位: MARSHALL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-23 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7110385
• 关键词: clinical research; neoplasm /cancer; transcription factor

DESCRIPTION (provided by applicant): Marshall University in the final stages of the development of the Edwards Cancer Center. Through the generosity of the Edwards family, funds are being used to construct a cancer center building and to establish an endowment. The new Cancer Building is currently being constructed and will be primarily a diagnostic and treatment facility. In light of these developments we are establishing a Cancer Research Center (CRC) that will complement and interdigitate with the clinical component of the Edwards Cancer Center. As part of this CRC we are proposing a COBRE entitled "Transcription Factors in Cancer" The COBRE consists of four projects and three cores. Project 1: "Beta catenin function and retinoic acid in melanoma", Beverly, Delidow, Principal Investigator will build on preliminary findings that retinoic acd reduces nuclear content and function of beta-catenin in melanoma to explore the consequences of this multifunctional protein in progression of human melanoma. Project 2: "Retinoids, NF-kB and Mn-SOD in Neuroblastoma", Kelley Kiningham, PI. will explore the hypothesis that Mn-SOD is required for retinoid-induced differentiation and that reactive oxygen species are involved in signaling. Project 3 "Sap, a potential zebrafish oncogene", Maiyon Park, Principal Investigator investigates the exciting finding that overexpression of sap in zebrafish embryos leads to tumor formation and will determine if a human oncogene counterpart is present is some human tumors. Project 4: "The role of Ski/Sno in testicular cancer", Laura Richardson, PI, deals with overexpression and function of this transcription factor in testicular cancer. These projects are supported by Administrative, Imaging and Genomics Cores. All projects deal with retinoids or its signaling pathway in a least a portion of their research. Thus there will be a great deal of interaction regarding common assays and reagents. This critical mass of investigators working on a common scientific theme with multiple interactions, supported by strong cores provides a unique opportunity for both career development of COBRE investigators and development of a nationally competitive research center.

描述（由申请人提供）： 马歇尔大学爱德华兹癌症中心处于发展的最后阶段。通过爱德华兹家族的慷慨解囊，资金被用于建造癌症中心大楼并设立捐赠基金。新的癌症大楼目前正在建设中，主要是一个诊断和治疗设施。鉴于这些发展，我们正在建立一个癌症研究中心 (CRC)，该中心将补充爱德华兹癌症中心的临床部分并与之相互配合。作为本 CRC 的一部分，我们提出了一个题为“癌症中的转录因子”的 COBRE COBRE 由四个项目和三个核心组成。项目 1：“黑色素瘤中的 β 连环蛋白功能和视黄酸”，首席研究员 Beverly Delidow 将基于视黄酸 acd 降低黑色素瘤中 β-连环蛋白的核含量和功能的初步发现，探索这种多功能蛋白在人类黑色素瘤进展中的影响。项目 2：“神经母细胞瘤中的类维生素A、NF-kB 和 Mn-SOD”，Kelley Kiningham，PI。将探讨以下假设：Mn-SOD 是类视黄醇诱导分化所必需的，并且活性氧参与信号传导。项目 3“Sap，一种潜在的斑马鱼致癌基因”，首席研究员 Maiyon Park 调查了这一令人兴奋的发现，即斑马鱼胚胎中 sap 的过度表达会导致肿瘤形成，并将确定某些人类肿瘤中是否存在人类致癌基因对应物。项目 4：“Ski/Sno 在睾丸癌中的作用”，Laura Richardson，PI，研究该转录因子在睾丸癌中的过度表达和功能。这些项目得到了管理、成像和基因组核心的支持。所有项目的至少一部分研究都涉及类维生素A或其信号通路。因此，关于常见的测定和试剂将会有大量的相互作用。在强大核心的支持下，这一数量足够的研究人员致力于共同的科学主题，并进行多种互动，为 COBRE 研究人员的职业发展和建设具有全国竞争力的研究中心提供了独特的机会。