Improving Care of Persons with Cognitive Impairment and their Caregivers

改善对认知障碍患者及其护理人员的护理

• 批准号: 7491939
• 负责人: Yueh-Feng Yvonne Lu
• 金额: $ 9.09万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-01 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7491939
• 关键词: Affect; Alzheimer' s Disease; Behavior Therapy; Biometry; Caregivers; Caring; Clinical; Clinical Research; Daily; Data; Dementia; Development; Discipline of Nursing; Doctor of Philosophy; Elderly; Emotional; Future; Impaired cognition; Intervention; Lead; Mental Depression; Mentorship; Methods; Numbers; Nursing Research; Outcome Measure; Patients; Persons; Pilot Projects; Quality of life; Randomized Controlled Clinical Trials; Rate; Research Activity; Risk; Scientist; Self Management; Staging; Testing; Time; Training; care giving burden; design; disability; improved; mild neurocognitive impairment; neuropsychological; prevent; productivity loss; size; skills

DESCRIPTION (provided by applicant): The candidate is a PhD nursing research scientist focusing on behavioral interventions to improve the care of older adults with mild cognitive impairment. The candidate seeks to obtain additional training in neuropsychological assessment, mixed methods biostatistics, multi-component clinical interventions, and collaborative clinical research in order to become an independent nursing scientist. She has assembled a multi-disciplinary mentorship team to assist her in her training and research activities. Mild cognitive impairment (MCI) affects as many as 20% of older adults, nearly three times the number affected by dementia. Previous studies have shown that persons with MCI are at high risk for developing Alzheimer disease (AD). MCI is associated with loss of productivity and difficulty in engaging in meaningful activities even before the development of dementia. These losses are associated with both premature disability and depression. There is a need for interventions targeted at the stage of MCI because at this early stage of cognitive decline, patients and their caregivers may have a critical window to develop important self-management skills that will prevent premature disability and disengagement. In the proposed study, the candidate will lead the development of a pilot study of the "daily enhancement of meaningful activities" (DEMA) intervention. It is hypothesized that identification of daily meaningful activities and engaging in these activities can improve physical and emotional function as well as quality of life. It is also hypothesized that the DEMA intervention will reduce care giving burden. Specific aims of this pilot study are: (1) to design and field-test the DEMA intervention among MCI patient caregiver dyads to assess desirability, feasibility, and acceptability; and (2) to obtain preliminary data on participation rates, effect size, and outcome measures for the DEMA intervention to plan for a future randomized controlled clinical trial.

描述（由申请人提供）：候选人是一名博士护理研究科学家，专注于行为干预，以改善轻度认知障碍老年人的护理。候选人寻求获得神经心理学评估，混合方法生物统计学，多组分临床干预和协作临床研究的额外培训，以成为独立的护理科学家。她组建了一个多学科的导师团队，以协助她在她的培训和研究活动。轻度认知障碍（MCI）影响多达20%的老年人，几乎是痴呆症患者的三倍。先前的研究表明，MCI患者患阿尔茨海默病（AD）的风险很高。MCI与生产力的丧失和参与有意义的活动的困难有关，甚至在痴呆症发展之前。这些损失与过早残疾和抑郁症有关。有必要针对MCI阶段进行干预，因为在认知能力下降的早期阶段，患者及其护理人员可能有一个关键的窗口来发展重要的自我管理技能，以防止过早残疾和脱离接触。在拟议的研究中，候选人将领导开展一项“每日加强有意义的活动”干预措施的试点研究。据推测，识别日常有意义的活动并参与这些活动可以改善身体和情感功能以及生活质量。还假设DEMA干预将减轻护理负担。这项试点研究的具体目的是：（1）设计和现场测试的DEMA干预MCI患者护理者的二人组，以评估可取性，可行性和可接受性;（2）获得初步数据的参与率，效果大小，和结果的措施，为DEMA干预计划未来的随机对照临床试验。