Role of Dcytb in dietary iron absorption

Dcytb 在膳食铁吸收中的作用

• 批准号: BB/F003056/1
• 负责人: Andrew McKie
• 金额: $ 48.35万
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2008
• 资助国家: 英国
• 起止时间: 2008 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FF003056%2F1
• 关键词: Role; Dcytb; dietary; iron; absorption

Iron is an essential nutrient required by our bodies to make red blood cells and enzymes involved in energy production in our muscles. Eating a diet poor in iron leads to anaemia (lack of haemoglobin in red blood cells) and changes in energy metabolism leading to tiredness and fatigue. It is estimated by WHO that iron deficient anaemia affects millions of people worldwide. On the other hand, too much iron is also a health problem as in the disease haemochromatosis, where too much iron is absorbed from the diet leading to iron accumulation in tissues including the liver, heart and pancreas. Excess iron is toxic to cells causing organ damage. Therefore iron absorption from the diet must be tightly controlled. Over the past few years medical advances have identified several proteins expressed in the gastrointestinal tract that are responsible for absorption of dietary iron. These proteins are regulated by the body's iron stores so that we absorb the correct amount of iron from our diet. Our work aims to study one of these proteins (named Dcytb for duodenal cytochrome b). By studying iron absorption in mice in which the Dcytb gene has been lost we will increase our understanding of absorption of an essential nutrient.

铁是我们身体所需的一种必需营养素，用于制造红细胞和参与肌肉能量生产的酶。饮食中缺乏铁会导致贫血（红细胞中缺乏血红蛋白）和能量代谢的变化，导致疲倦和疲劳。据世卫组织估计，缺铁性贫血影响着全世界数百万人。另一方面，过多的铁也是一个健康问题，如血色病，其中从饮食中吸收过多的铁，导致铁积累在组织中，包括肝脏，心脏和胰腺。过量的铁对细胞有毒，导致器官损伤。因此，必须严格控制饮食中的铁吸收。在过去的几年里，医学进步已经确定了几种蛋白质在胃肠道中表达，负责膳食铁的吸收。这些蛋白质由身体的铁储备调节，以便我们从饮食中吸收正确数量的铁。我们的工作旨在研究这些蛋白质之一（命名为DcytB的十二指肠细胞色素B）。通过研究Dcytb基因丢失的小鼠的铁吸收，我们将增加我们对必需营养素吸收的理解。