Assessment of viral loads as markers of disease status in HIV and HPV positive

评估病毒载量作为 HIV 和 HPV 阳性疾病状态的标志

• 批准号: 7474493
• 负责人: Omar Bagasra
• 金额: $ 30.44万
• 依托单位: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-19 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7474493
• 关键词: AIDS related cancer; Acquired Immunodeficiency Syndrome; Address; African American; Age; American; Basic Science; Behavioral; Biological Markers; Blood; Caring; Caucasians; Caucasoid Race; Communicable Diseases; Communities; Community Health; Community Outreach; Complex; Data; Development; Diabetes Mellitus; Disease; Disease Marker; Education; Genotype; HIV; Hand; Head; Health Services Accessibility; Health Status; Health care facility; Healthcare; Herpesviridae; Highly Active Antiretroviral Therapy; Human; Human Herpesvirus 8; Human Papillomavirus; Human papillomavirus 16; Individual; Kaposi Sarcoma; Knowledge; Laboratories; Low income; Measurement; Medical; Messenger RNA; Minority; Molecular Virology; Obesity; Outcome Study; Outreach Research; Pap smear; Participant; Pilot Projects; Play; Population; Prevention; Quality of life; RNA; Race; Rate; Recruitment Activity; Research; Research Personnel; Research Project Grants; Resources; Role; Sexually Transmitted Diseases; Social support; Socioeconomic Status; Stigmata; Translating; Underserved Population; Viral Load result; Woman; disorder prevention; health belief; health disparity; mortality; outreach; outreach program; prevent; social stigma; success; transmission process

In recent years, the overall AIDS and AIDS associated cancer mortality in the U.S. has significantly decreased, but the decrease has not been consistent across all populations. Due to an array of barriers to care, minorities and poor people who are infected with the human immunodeficiency virus type I (HIV) and various other sexually transmitted diseases (i.e., human herpes virus type 8 [HHV-8] and human papillomavirus [HPV]) have not benefited from advances in the treatment of HIV and HIV associated diseases as other groups. Minorities are acquiring HIV (and other sexually transmitted infectious diseases) at much higher rates than observed in Caucasians. African American (AA) women are the fastest growing group of HIV positive individuals. Our proposal addresses this issue by developing a partnership between the researchers, the established health care facilities, community outreach groups and education initiatives to close the gaps in these philosophical differences, realize the limitations, and reach out to the medical community, researcher, as well as the public to reduce the health disparities. It focuses specifically on consolidation of the resources between various groups to maximize health care for the underserved populations in SC. We believe that the outcome of this study will benefit all the underserved groups in the nation The five specific aims of this project are: 1) to establish a molecular virology laboratory to serve as a core research resource for the EXPORT collaborating researchers 2) to collect and provide data on HIV-1 in HIV-1 seropositive individuals recruited for participation in the projects of Drs. Hand and Phillips and Drs. Stoskopf and Geslani, 3) to provide quantitative assessment of HPV 16 and 18 E7 mRNA, sequencing and genotyping of HPV, and HPV viral load from Pap smears collected from the other full research project headed by Drs. Creek and Pirisi, 4) to determine HHV-8 viral loads in HIV-1 seropositive individuals for this research project and then to 5) investigate any correlation(s) between the development of full blown AIDS, and KS.

近年来，美国艾滋病和与艾滋病相关的癌症死亡率总体上显著下降，但下降幅度在所有人群中并不一致。由于护理方面存在一系列障碍，感染了人类免疫缺陷病毒I型(艾滋病毒)和其他各种性传播疾病(即人类8型疱疹病毒[HHV-8]和人乳头瘤病毒[HPV])的少数群体和穷人没有像其他群体那样从艾滋病毒和艾滋病毒相关疾病的治疗进展中受益。少数民族感染艾滋病毒(和其他性传播传染病)的比率比高加索人高得多。非洲裔美国人(AA)妇女是艾滋病毒阳性个体中增长最快的群体。我们的建议通过在研究人员、现有的卫生保健机构、社区外展团体和教育倡议之间建立伙伴关系来解决这一问题，以弥合这些哲学差异中的差距，认识到局限性，并接触医学界、研究人员和公众，以减少健康差距。它特别侧重于整合不同群体之间的资源，以最大限度地为南卡罗来纳州未得到充分服务的人口提供保健服务。我们相信，这项研究的结果将使全国所有未得到充分服务的群体受益。该项目的五个具体目标是：1)建立一个分子病毒学实验室，作为出口合作研究人员的核心研究资源；2)收集和提供参与Hand博士和Phillips博士以及Stoskopf博士和Geslani博士项目的HIV-1血清阳性个体中HIV-1的数据；3)提供HPV 16和18 E7 mRNA的定量评估，HPV的测序和基因分型，以及从由Drs.Creek和Pirisi领导的另一个完整研究项目收集的巴氏涂片中HPV病毒载量，4)检测HIV-1血清阳性患者的HHV-8病毒载量 然后对个人进行这个研究项目，以调查(S)艾滋病的全面发展与KS之间的任何相关性。