Interactions between Notch signalling and SoxB transcription factors during the development and regeneration of sensory hair cells

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The inner ear contains different sensory organs responsible for hearing and the perception of head movements. Each sensory organ contains a limited number of sensory cells, named hair cells. In mammals, the loss of auditory hair cells following a noise trauma, ototoxicity, or during aging is irreversible and causes permanent deafness. But in birds, fish and amphibians, inner ear hair cells are produced throughout life and regenerate following tissue injury. Our main objective is to identify the genes and signals involved in the production of hair cells during embryonic development and their post-traumatic regeneration in the chick inner ear. In the long term, our findings could contribute to the development of new therapies for deafness.