权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Interactions between Notch signalling and SoxB transcription factors during the development and regeneration of sensory hair cells

感觉毛细胞发育和再生过程中Notch信号传导和SoxB转录因子之间的相互作用

基本信息

批准号：
BB/F007175/1
负责人：
Nicolas Daudet
金额：
$ 44.25万
依托单位：
University College London
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2008
资助国家：
英国
起止时间：
2008 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=BB%2FF007175%2F1
关键词：
Interactions between Notch signalling SoxB

项目摘要

The inner ear contains different sensory organs responsible for hearing and the perception of head movements. Each sensory organ contains a limited number of sensory cells, named hair cells. In mammals, the loss of auditory hair cells following a noise trauma, ototoxicity, or during aging is irreversible and causes permanent deafness. But in birds, fish and amphibians, inner ear hair cells are produced throughout life and regenerate following tissue injury. Our main objective is to identify the genes and signals involved in the production of hair cells during embryonic development and their post-traumatic regeneration in the chick inner ear. In the long term, our findings could contribute to the development of new therapies for deafness.

内耳包含不同的感觉器官，负责听觉和头部运动的感知。每个感觉器官都包含有限数量的感觉细胞，称为毛细胞。在哺乳动物中，噪声创伤、耳毒性或衰老过程中听觉毛细胞的丧失是不可逆的，并导致永久性耳聋。但在鸟类、鱼类和两栖动物中，内耳毛细胞在整个生命过程中都会产生，并在组织损伤后再生。我们的主要目标是确定基因和信号参与毛细胞的生产过程中胚胎发育和创伤后再生鸡内耳。从长远来看，我们的发现可能有助于开发新的耳聋疗法。

项目成果

期刊论文数量（7）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Absence of plastin 1 causes abnormal maintenance of hair cell stereocilia and a moderate form of hearing loss in mice.

塑蛋白1的缺失会导致毛细胞立体胶质的异常维持和小鼠的听力丧失形式。

DOI：
10.1093/hmg/ddu417
发表时间：
2015-01-01
期刊：
Human molecular genetics
影响因子：
3.5
作者：
Taylor R;Bullen A;Johnson SL;Grimm-Günter EM;Rivero F;Marcotti W;Forge A;Daudet N
通讯作者：
Daudet N

Artificial induction of Sox21 regulates sensory cell formation in the embryonic chicken inner ear.

DOI：
10.1371/journal.pone.0046387
发表时间：
2012
期刊：
PloS one
影响因子：
3.7
作者：
Freeman SD;Daudet N
通讯作者：
Daudet N

Supporting cells eliminate dying sensory hair cells to maintain epithelial integrity in the avian inner ear.

DOI：
10.1523/jneurosci.3042-10.2010
发表时间：
2010-09-15
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
0
作者：
Bird JE;Daudet N;Warchol ME;Gale JE
通讯作者：
Gale JE

Notch regulation of progenitor cell behavior in quiescent and regenerating auditory epithelium of mature birds.

DOI：
10.1016/j.ydbio.2008.10.033
发表时间：
2009-02-01
期刊：
DEVELOPMENTAL BIOLOGY
影响因子：
2.7
作者：
Daudet, Nicolas;Gibson, Robin;Shang, Jialin;Bernard, Amy;Lewis, Julian;Stone, Jennifer
通讯作者：
Stone, Jennifer

Tol2-mediated gene transfer and in ovo electroporation of the otic placode: a powerful and versatile approach for investigating embryonic development and regeneration of the chicken inner ear.