HIV INTEGRASE SH3 INTERACTIONS

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. HIV integrase is the virus's third enzyme (the other two are reverse transcriptase and protease). HIV uses integrase to incorporate its genes into a host cell's DNA. Inhibition of HIV integrase is an attractive therapeutic strategy since it would potentially protect healthy cells from infection thereby helping to bolster the immune system. We are currently investigating integrase SH3 interactions.