COMBINATORIAL SYNTHESIS OF PHOSPHINE LIGANDS

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Our research is centered on the development of new synthetic methods and the utilization of synthetic chemistry for the study of important biological and medical problems. The projects in our laboratory range from the development of new methods in organic synthesis and the total synthesis of biologically important natural products to medicinal chemistry around leads compounds. Doing synthetic chemistry at UTMB provides us with a unique opportunity to test the biological activity of our compounds and make modifications to improve activity or test important biological principles. Some of the projects we are currently working on are: Development of chemistry for small molecule library synthesis Total synthesis and medicinal chemistry of biologically important natural products Rhodium catalyzed synthesis of medium sized rings Peptide based catalysts