The development of a novel transgenic technology

新型转基因技术的开发

• 批准号: BB/F018339/1
• 金额: $ 10.26万
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Training Grant
• 财政年份: 2008
• 资助国家: 英国
• 起止时间: 2008 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FF018339%2F1
• 关键词: development; novel; transgenic; technology

Atazoa Ltd have found that spermatozoa present in farm animal ejaculates, which are widely used for breeding purposes, can be genetically modified. At present this genetic modification consists of introducing a gene into spermatozoa that encodes a green fluorescent protein (GFP), which can be easily seen by microscopy. This protein is of no therapeutic value in itself but it does provide a simple means to test and improve upon the techniques that are required to introduce genes into sperm. It will also allow us to test whether genes that are introduced into sperm by this method can be inherited through in vitro fertilisation and at what efficiency. This type of technology is potentially of great value because current means of introducing genes into larger animals are very inefficient and expensive. The new technology proposed here promises to facilitate the breeding of genetically modified animals, which are already known to be of great value for the development and discovery of new therapeutic treatments.

Atazoa有限公司发现，广泛用于育种目的的家畜精液中的精子可以进行基因改造。目前，这种基因修饰包括将编码绿色荧光蛋白（GFP）的基因导入精子，这种荧光蛋白可以很容易地通过显微镜观察到。这种蛋白质本身没有治疗价值，但它确实提供了一种简单的方法来测试和改进将基因导入精子所需的技术。它还将使我们能够测试通过这种方法引入精子的基因是否可以通过体外受精遗传，以及效率如何。这种技术具有潜在的巨大价值，因为目前将基因引入大型动物的方法效率很低，而且成本很高。这里提出的新技术有望促进转基因动物的繁殖，众所周知，转基因动物对开发和发现新的治疗方法具有重要价值。