Core--Animal Model Laboratory

动物模型实验室核心将与SPIRP研究人员合作，进一步了解 高血压和其他特定的血管危险因素对高血压病理生理学的影响 脑血管疾病动物实验室的长期目标是进一步了解高血压和其他特定血管危险因素在脑血管疾病病理生理学中的作用。该实验室将与SPIRP的其他组成部分相结合，以支持基本科学原理在制定预防中风和其他脑血管疾病的措施中的临床应用。第一阶段的具体目标是：1）在MSM-SPIRP中建立一个互动的研究者工作组，这些研究者都对开发新的卒中治疗方法感兴趣 通过进一步阐明中风易感性、神经保护和血管性痴呆的病理生物学来预防，2）在具有实验性中风、神经保护和血管生物学专业知识的莫尔豪斯医学院研究人员与具有磁共振成像和行为神经科学专业知识的埃默里大学研究人员之间开展合作，3）优化MR成像方案，以使用良好表征的卒中模型测量脑损伤和脑灌注的变化：大脑中动脉闭塞模型，4）通过体内MR等补充方法表征高血压相关脑微血管疾病模型及其对脑结构和功能的影响 使用Dahl盐敏感大鼠模型进行成像研究; 5）使用Dahl盐敏感大鼠模型和SPIRP、神经科学研究所和心血管研究所支持的研究人员使用或开发的其他动物模型支持进一步的中风预防研究，这些研究人员专注于了解脑血管疾病的机制和预防。II期的具体目标是：1）基于I期研究结果实施神经保护干预实验方法; 2）促进脑缺血基础研究结果应用于临床干预研究。

The Animal Model Laboratory Core will work with SPIRP investigators to further understand the contribution of hypertension and other specific vascular risk factors to the pathophysiology of cerebrovascular disease. The long-term goal of the animal laboratory is to further understand the role of hypertension and other specific vascular risk factors in the pathophysiology of cerebrovascular disease. This laboratory will be integrated with the other components of the SPIRP in order to support bench-to-bedside application of basic scientific principles in the development of measures designed to prevent stroke and other cerebrovascular disease. The specific aims in Phase I will be 1) to establish an interactive working group of investigators within the MSM-SPIRP who share an interest in developing novel approaches to stroke prevention by further elucidating the pathobiology of stroke susceptibility, neuroprotection and vascular dementia, 2) to develop collaborations between Morehouse School of Medicine investigators, with expertise in experimental stroke, neuroprotection, and vascular biology, and Emory University investigators with expertise in magnetic resonance imaging and behavioral neuroscience, 3) to optimize MR imaging protocols to measure brain injury and changes in cerebral perfusion using a well-characterized stroke model: the middle cerebral artery occlusion model, 4) to characterize a model of hypertension-related cerebral microvascular disease and its effect on brain structure and function by complementary methodologies such as in vivo MR imaging using the Dahl salt-sensitive rat model, and 5) to support further stroke prevention studies using the Dahl salt-sensitive rat model and other animal models used or developed by SPIRP-, Neuroscience Institute-, and Cardiovascular Research Institute-supported investigators focused on understanding the mechanisms and prevention of cerebrovascular disease. The specific aims in Phase II will be 1) to implement neuroprotective intervention experimental approaches based upon outcomes of studies from Phase I, and 2) to facilitate the application of findings from basic research on cerebral ischemia to clinical intervention research.