New Photo-Releasable Iron Complexes

这项提议涉及到铁的络合物的发展，当暴露在特定波长的光下时，这些络合物会坍塌，从而在被照射的表面释放铁。这些新的化学工具将有助于研究生物过程，这些过程被认为是由于Fe(III)从正常的隔离状态释放而产生的。这种可光崩解的复合体将提供对通过遥控光研究的生物系统中释放的Fe(III)的空间、时间和浓度的精确控制。这些化学工具将专门用于模拟导致血液凝固或血栓形成的过程。Fe(III)被广泛用于在模型中诱导血栓形成，但目前通过将浸泡在铁溶液中的滤纸放置在研究部位上的方式控制很差。这项建议寻求开发一种更精确的铁管理方法，可能提供对导致血栓形成的机制的更详细的了解。凝血是健康生物体的一个重要特征，可以保护血管免受损伤，但血栓的形成和由此导致的血管闭塞是衰老和许多疾病状态的特征，通常会造成致命的后果。导致这一事件的机制很复杂，是一个重要的研究领域，因为这种理解可能与健康和福利直接相关。Fe(III)通常与其他组织损伤过程有关，如关节炎，因为它可以催化与氧化应激相关的自由基物种的形成。因此，拟议中的化学工具提供了对铁水平的精确控制，因此可能会吸引广泛的研究人员。

This proposal concerns the development of iron complexes that collapse upon exposure to specific wavelengths of light to release iron at the illuminated surface. These novel chemical tools will be useful for studying biological processes believed to arise from the release of Fe (III) from their normal sequestered state. Such photo-collapsible complexes will offer precise control over the space, time and concentration Fe(III) released in a biological system under study by the remote-control of light. These chemical tools will specifically be used to model processes leading to blood coagulation or thrombosis. Fe (III) is widely used to induce thrombosis in models, but is currently administered in a very poorly controlled way by placing filter paper soaked in the iron solution onto the site under study. This proposal seeks to develop a more precise method of administering iron that may provide more detailed understanding of the mechanisms leading to thrombus formation. Blood coagulation is an important feature of the healthy organism, protecting against injury to the vasculature, but the formation of thrombosis and the resulting occlusion of blood vessels is a feature of aging and many disease states, often with fatal consequences. The mechanisms leading to this event are complex and are an important area of study since this understanding may be directly relevant to health and welfare. Fe (III) is often implicated in other tissue damage processes, such as arthritis, because it can catalyse the formation of radical species associated with oxidative stress. The precise control over iron levels offered the proposed chemical tool may therefore be attractive to a wide range of researchers.