Artificial Ligament with Bioactive Nanostructure (ALBioN)

该项目将开发一种医疗设备，用于再生修复撕裂的韧带，使用平台技术生产基于胶原蛋白、糖胺聚糖和生物活性磷酸钙的智能纳米复合材料。其目的是开发一种能够取代完整的前十字韧带的移植物。这项技术也适用于要求较低的韧带供体部位修复。将研究胶原纤维长度、工艺参数和交联度对材料结构和性能的影响，以便进行量身定制的移植物设计。

This project will develop a medical device for the regenerative repair of torn ligaments using a platform technology for the production of smart, nanocomposite materials based on collagen, glycosaminoglycans and a bioactive calcium phosphate. The aim is to develop a graft which is capable of replacing the full anterior cruciate ligament. The technology will also be appropriate for the much less demanding application of ligament donor site repair. The effects of collagen fibril length, process parameters and cross-link density on the stucture and properties of the materials will be studied, allowing tailored design of the graft.