Radiolabeling, Quality Control, and Immunoassays

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The Radiolabeling, Quality Assurance, and Immunoassay Core will provide a variety of services for the participants of this Program Project. This Core Facility has been providing these same services to CMMI investigators for 20 years. The primary responsibility of this core involves the preparation of radiolabeled agents for investigators. This includes the processing, receipt, preparation, quality assurance and disposal of the radiolabeled materials. This laboratory has experience in preparing radiolabeled antibodies and peptides with 1311,1251,123I, " V 90Y, 188Re, 99mTc, 212Bi, and 67Ga. Each product that is produced undergoes a series of quality assurance checks, including ITLC, size-exclusion HPLC, and Immunoreactivity determinations. All equipment used in this laboratory is calibrated regularly and all procedures are performed under SOPs. This laboratory also produces radiolabeled investigational agents for a number of INDs, and has experience in developing procedures to ensure product stability when shipped to extramural investigational sites. This core is also involved in the processing of blood and urine samples used for pharmacokinetic analysis, as well as plasma samples for anti-antibody assays. This Core will be utilized by Projects 1,2, and 4.