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Hepatocellular Carcinoma: understanding the genotoxic risks of liver-targeted gene therapy using recombinant AAV vectors

Hepatocellular Carcinoma: understanding the genotoxic risks of liver-targeted gene therapy using recombinant AAV vectors
肝细胞癌：了解使用重组 AAV 载体进行肝脏靶向基因治疗的基因毒性风险
批准号：
nhmrc : GNT1145116
负责人：
Prof Geoffrey McCaughan
金额：
$89.16万
依托单位：
依托单位国家：
澳大利亚
项目类别：
Project Grants
财政年份：
2018
资助国家：
澳大利亚
项目状态：
已结题
起止时间：
2018-01-01 至 --
来源：
https://researchdata.edu.au/hepatocellular-carcinoma-understanding-aav-vectors/1348661
关键词：
HepatocellularCarcinomaunderstandinggenotoxicrisks

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中文摘要
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英文摘要
Advances in gene transfer technology using an engineered virus known as AAV underpin success in the treatment of haemophila B, and offer the exciting prospect of treating many other liver diseases. While continued improvement of gene transfer efficiency is essential there is an equal need to focus on safety. We have discovered a genetic element in AAV that we believe is a key to unlocking accurate analysis of the safety of AAV-based gene transfer technology. Here we propose to turn the key.
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A novel liver cancer therapy targeting tumour stroma
  • 批准号：
    nhmrc : GNT1113842
  • 项目类别：
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  • 资助金额：
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    2016
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    Prof Geoffrey McCaughan
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  • 财政年份：
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  • 负责人：
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