Heterogeneity of airway smooth muscle remodelling in asthma

哮喘气道平滑肌重塑的异质性

• 批准号: nhmrc : 1141552
• 负责人: Dr Annette Mcwilliams
• 金额: $ 42.13万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/heterogeneity-airway-smooth-remodelling-asthma/1319497
• 关键词: Heterogeneity; airway; smooth; muscle; remodelling

Increased smooth muscle in the airways causes excessive narrowing and asthma symptoms. The distribution of the increased muscle in the lung varies between people with asthma and may determine how severe the asthma is and what treatments are best. This project will use tissues from many cases of asthma to map this distribution and will use laser scanning in the airways to develop a test to safely examine the smooth muscle in living people, in order to better treat or prevent asthma.

气道平滑肌的增加导致过度狭窄和哮喘症状。不同哮喘患者肺部肌肉的分布不同，这可能决定了哮喘的严重程度和最好的治疗方法。这个项目将使用来自许多哮喘病例的组织来绘制这种分布，并将在气道中使用激光扫描来开发一种测试，以安全地检查活人的平滑肌，以便更好地治疗或预防哮喘。