GERMPLASM & PHYTOCHEMICAL PROFILING/NIKOLAU, BASIL

种质质

• 批准号: 7293904
• 负责人: DIANE F BIRTH
• 金额: $ 24.77万
• 依托单位: IOWA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7293904
• 关键词: Biochemical; Biochemical Genetics; Botanicals; Characteristics; Chemicals; Clinical Trials; Collection; Communities; Condition; Controlled Environment; Cues; Data; Data Collection; Databases; Development; Echinacea (Asteraceae); Echinacea Preparation; Environment; Fingerprint; Health Benefit; Human; Hypericum; Information Networks; Information Resources; Internet; Iowa; Laboratory Research; Lead; Medicinal Plants; Methods; Ocimum basilicum; Phytochemical; Plants; Population; Production; Prunella (angiosperm); Range; Recommendation; Research; Research Personnel; Research Project Grants; Risk; Role; Seeds; Sorting - Cell Movement; Source; Support of Research; Surveys; System; Universities; Variant; design; dietary supplements; improved; metabolomics; plant growth/development; tool

Core A of the Iowa Center for Botanical Supplement Research has five long-term objectives in support of the research being conducted within the Center to improve our understanding of the human health benefits and potential risks of the dietary supplements, Echinacea, Hypericum, and Prunella. First, we will expand comprehensive plant germplasm collections of Echinacea and Hypericum, and develop collections of Prunella, in a manner designed to represent a broad range of taxonomic,genetic and biochemical diversity, and to propagate the plants through control-pollinated seed production and vegetative means. In this way, these well-documented and characterized plant collections will be made available for research by Center investigators and the broader research community. Second, we will actively curate these medicinal plant germplasm collections at the North Central Regional Plant Introduction Station (NCRPIS) as part of the US National Plant Germplasm System, along with all data associated with their origins, taxonomic identities, and biochemical characteristics, which will be made available via the Internet in the Germplasm Resources Information Network (GRIN) database. Third, we will produce vegetative materials of known-source populations of these plants under controlled conditions at the NCRPIS, through both field and controlled-environment culture, to serve as well- characterized plant materials for the Center's research projects. Fourth, we will conduct fingerprint analyses and chemical identification of the phytochemicals found in these plants by conducting analytical research at Iowa State University's W.M. Keck Metabolomics Research Laboratory. And finally, we will survey the effects of environmental and developmental cues on the phytochemical fingerprints of germplasm collections of Echinacea, Hypericum, Prunella, focusing on Prunella, where little is known about the roles of environment and plant development on its chemical profiles. These core activities provide valuable tools that allow researchers, who study the bioactive and toxic components of these botanical supplements, methods for sorting out variation among plant species and populations being used as sources for these supplements. This has been a complicating factor in the study of all botanical supplements. By using known-source materials that are well characterized biochemically, Center researchers can more efficiently identify bioactive components, and make recommendations that lead to better clinical trials to maximize the human health benefits from these supplements while minimizing risks to consumers.

爱荷华州植物补充剂研究中心的核心A有五个长期目标来支持 该中心正在进行研究，以提高我们对人类健康益处和 膳食补充剂、紫锥菊、金丝桃和夏枯草的潜在风险。 一是扩大紫锥菊、金丝桃属综合植物种质资源，发展 夏枯草的收集，以一种旨在代表广泛的分类学、遗传学和 生物化学多样性，并通过控制授粉种子生产和营养繁殖植物 意思是。通过这种方式，这些记录良好和具有特色的植物收藏将被提供给 中心调查人员和更广泛的研究社区进行的研究。 第二，积极开展中北部地区药用植物种质资源收藏工作 植物引种站(NCRPIS)，作为美国国家植物种质系统的一部分，以及所有数据 与它们的起源、分类特征和生化特征相关联，这将被 可通过互联网在种质资源信息网(GRIN)数据库中获得。 第三，我们将生产这些植物的已知来源种群的营养材料。 NCRPIS的条件，通过田间和受控环境培养，也服务于- 为该中心的研究项目确定植物材料的特性。 第四，我们将对这些植物中发现的植物化学物质进行指纹分析和化学鉴定。 在爱荷华州立大学W.M.凯克代谢组学研究中心进行分析研究 实验室。 最后，我们将考察环境和发育线索对植物化学的影响。 紫锥菊、金丝桃、夏枯草种质资源的指纹图谱，集中在夏枯草上，那里几乎没有 了解环境和植物发展对其化学组成的影响。 这些核心活动提供了宝贵的工具，使研究人员能够研究生物活性和毒性 这些植物补充剂的成分，植物物种间变异的分类方法和 人口被用作这些补充剂的来源。这是这项研究中的一个复杂因素 在所有的植物补充剂中。通过使用生化特性良好的已知来源材料， 中心的研究人员可以更有效地识别生物活性成分，并提出建议 更好的临床试验，以最大限度地提高这些补充剂对人类健康的益处，同时将风险降至最低 对消费者来说。