The Texas Medical Center Regional Coordinating Center for Heart Failure

德克萨斯医疗中心心力衰竭区域协调中心

• 批准号: 7486279
• 负责人: Anita Deswal
• 金额: $ 35.43万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-30 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7486279
• 关键词: Adult; Advocate; Age; All Sites; Autologous; Basic Science; Biological; Biological Markers; Biological Neural Networks; Bone Marrow; C-reactive protein; CA-125 Antigen; Cardiac; Cells; Characteristics; Childhood; Chronic; Clinical; Clinical Research; Clinical Trials; Collaborations; Collagen; Communities; Complex; Conduct Clinical Trials; Dental Schools; Device Removal; Dobutamine Stress Echocardiography; Elderly; Eligibility Determination; Endothelial Cells; Endothelin-1; Enrollment; Ensure; Experimental Animal Model; Factor VIII-Related Antigen; Forensic Medicine; Gender; Glomerular Filtration Rate; Goals; Heart Transplantation; Heart failure; Hospice Care; Hospitals; Housing; Image; Inflammation; Injection of therapeutic agent; Institution; Judgment; Left Ventricular Remodeling; Medical center; Medicine; Mesenchymal; Minority; Mononuclear; Muscle Cells; Myocardial; Myocardial Ischemia; N-terminal; Necrosis; Numbers; Nursing Schools; Patients; Pediatric Hospitals; Peptides; Pharmacy facility; Phase; Phenotype; Population; Public Health Schools; Race; Recovery; Recruitment Activity; Regional Blood Flow; Research; Research Personnel; Safety; Schools; Science; Sensitivity and Specificity; Series; Site; Stem cells; Stress; System; Systolic heart failure; Teaching Hospitals; Testing; Texas; Therapeutic; Time; Transplant Recipients; Troponin T; Tumor Markers; United States National Institutes of Health; VWF gene; Ventricular; Visit; Weaning; Woman; Work; abstracting; acute coronary syndrome; base; cell type; college; experience; follow-up; functional status; hemodynamics; hospice environment; improved; medical schools; medical specialties; post gamma-globulins; pro-brain natriuretic peptide (1-76); prospective; racial and ethnic; stem cell therapy; tool; von Willebrand Factor

DESCRIPTION (provided by applicant): The Texas Medical Center Regional Coordinating Center for Heart Failure The proposed Texas Medical Center (TMC) Regional Coordinating Center (RCC) will be comprised of nine separate sites that are housed on the campus of the Texas Medical Center (www.tmc.edu), one of the largest incorporated medical centers in the world, with 42 not-for-profit institutions including 13 hospitals, two medical schools, two graduate schools of biomedical sciences, a dental school, four nursing schools, a school of public health, a college of pharmacy, a hospice facility, a geriatric center, a psychiatric center, and a forensic medical center, all located on the same campus. There are over 5,000,000 patient visits to the TMC, annually, which makes the TMC an ideal site to conduct clinical trials. Moreover, the racial and ethnic diversity within the TMC lends itself well to conducting clinical trials. The scientific and administrative base of this proposed RCC will be at Baylor College of Medicine. The nine sites in the TMC RCC are in close proximity to one another (see Figure 1), and most are attached by skywalks and tunnels that facilitate the interaction and collaboration between the sites. The patient characteristics, experience in clinical research in heart failure and enrollment capacity for heart failure clinical trials at each of the participating institutions is outstanding. Finally, the proposed TMC RCC has a number of unique features that are ideally suited for the NIH heart failure research network, including close proximity of all participating Institutions to one another such that a single research coordinator can recruit from all sites in the TMC network, sufficient racial diversity of the patient population to ensure adequate recruitment of minorities and women, a mixture of community and teaching hospitals, pediatric and adult hospitals, and specialty hospitals (e.g. MD Anderson), each of which has a very high patient volume for adult and pediatric heart failure. Finally the TMC RCC will be overseen by Dr. Douglas Mann, who has experience with phase I - IV clinical trials, and who has close working relationship with of the investigators in the proposed TMC RCC by virtue of his 14 year tenure in the Texas Medical Center. (End of Abstract)

描述（由申请人提供）： 德克萨斯州医疗中心心力衰竭区域协调中心 拟议中的德克萨斯医疗中心（TMC）区域协调中心（RCC）将由9个独立的站点组成，位于德克萨斯医疗中心（www.example.com）的校园内www.tmc.edu，德克萨斯医疗中心是世界上最大的合并医疗中心之一，拥有42个非营利机构，包括13家医院，两所医学院，两所生物医学科学研究生院，一所牙科学校，四所护士学校，一所公共卫生学院、一所药学院、一所临终关怀机构、一所老年病中心、一所精神病中心和一所法医中心，都设在同一个校园内。每年有超过5，000，000名患者访问TMC，这使得TMC成为进行临床试验的理想场所。此外，TMC内部的种族和民族多样性很适合进行临床试验。这个拟议的RCC的科学和行政基地将在贝勒医学院。TMC RCC的九个站点彼此非常接近（见图1），大多数站点都通过人行天桥和隧道连接，以促进站点之间的互动和协作。各参与机构的患者特征、心力衰竭临床研究经验和心力衰竭临床试验的入组能力均非常出色。最后，拟议的TMC RCC具有许多非常适合NIH心力衰竭研究网络的独特功能，包括所有参与机构彼此靠近，使得单个研究协调员可以从TMC网络的所有站点招募，患者人群的种族多样性足以确保少数民族和女性的充分招募，社区和教学医院的混合，儿科和成人医院以及专科医院（例如MD安德森），每一家医院都有非常高的成人和儿科心力衰竭患者量。最后，TMC RCC将由道格拉斯曼博士监督，他具有I-IV期临床试验的经验，并且由于他在德克萨斯州医学中心的14年任期，他与拟议的TMC RCC的研究者有密切的工作关系。(End摘要）