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中文摘要
翻译
酒吧!2型糖尿病合并稳定型冠心病的临床研究。谁是冠状动脉的候选者
英文摘要
The BAR!II trial of type 2 diabetic patients with stable CAD.who are candidates for coronary revascularization will test 1) if an initial strategy of revascularization (PTCA or CABG) and aggressive medical management of diabetes results in lower 5 year mortality compared to aggressive medical management with an initial strategy of delayed or no revascularization, and 2) the optimal approach of hyperglycemia management in the setting of.auniform HbAjC goal. The long-term objective and specific aims of this proposal are to classify all ECG documents associated with BARIII patients to identify baseline ECG predictors of long-term outcome, and to classify all myocardial infarct/ischemic events associatedwith the treatment strategies tested over 5 years of follow-up. Myocardial ischemic events will be classifed by serial ECG changes, cardiac enzyme abnormalities, and clinical symptoms. Myocardial infarction is defmedj as Q wave (symptomatic or silent detected during routine follow-up), non Q wave MI, or unstable angina associated with or without new ECG changes resulting in hospital admission; Serial ECG change will be detected using the Novacode, an ECG comparison program used in large scale clinical trials. Cardiac enzyme abnormalities will be classified using WHO criteria. The results of this proposal will allow determination of myocardial ischemic event rates in BARI II, a major study secondary endpoint. The rates of myocardial infarction and myocardial ischemic events leading to hospital admission will be compared in patients randomized to initial medical therapy or initial coronary revascularization, and to insulin providing diabetes treatment protocol vs. insulin sensitizing diabetes treatment protocol. The prognostic impact of baseline and subsequent new follow-up ECG changes will be determined for cardiac mortality and total mortality. DERFORMANCE SITE(S) (organization, city, state) St. Louis University Core Myocardial Infarct/Ischemia/ECG laboratory 1034 South Brentwood Blvd. Suite 1550 St. Louis, MO 63117 KEY PERSONNEL. See instructions on Page 11. Use continuation pages as neededto provide the required information in the format shown below. Name Organization ¿ Role on Project Bernard R. Chaitman, M.D. St. Louis Univ. School of Med. PI Jerome D. Cohen, M.D. St. Louis Univ. School of Med. Study investigator Igor Gussak, M.D.,PhD St. Louis Univ. School of Med. Study Investigator Karen Stocke, MBA St. Louis Univ. School of Med. Laboratory Supervisor PHS 398 (Rev. 4/98) Page 2 BB Number pages consecutively at the bottom throughout the application. Do not use suffixes such as 3a, 3b. CC Principal Ii<ftgator/Proqram Director (Last, first, middle): ¿b Chaitman" Bernard R Type the name of the principal'investigator/program director at the top of each printed page and each continuation page. (For type specifications, see instructions on page 6.) RESEARCH GRANT TABLE OF CONTENTS Page Numbers Face Page 1 Description,
期刊论文(51)
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会议论文
DOI: 10.1056/nejmoa1415921
发表时间: 2015-08-13
期刊: The New England journal of medicine
影响因子: --
作者: [Everett BM, Brooks MM, Vlachos HE, Chaitman BR, Frye RL, Bhatt DL, BARI 2D Study Group]
通讯作者: BARI 2D Study Group
Baseline characteristics of patients with diabetes and coronary artery disease enrolled in the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) trial.
参加旁路血管成形术血运重建调查 2 糖尿病 (BARI 2D) 试验的糖尿病合并冠状动脉疾病患者的基线特征。
DOI: 10.1016/j.ahj.2008.05.015
发表时间: 2008
期刊: American heart journal
影响因子: 4.8
作者: [BypassAngioplastyRevascularizationInvestigation2DiabetesStudyGroup]
通讯作者: BypassAngioplastyRevascularizationInvestigation2DiabetesStudyGroup
Race/ethnic disparities in risk factor control and survival in the bypass angioplasty revascularization investigation 2 diabetes (BARI 2D) trial.
旁路血管成形术血运重建调查 2 型糖尿病 (BARI 2D) 试验中危险因素控制和生存的种族/民族差异。
DOI: 10.1016/j.amjcard.2013.05.071
发表时间: 2013
期刊: The American journal of cardiology
影响因子: --
作者: [Beohar,Nirat, Sansing,VeronicaV, Davis,AndrewM, Srinivas,VS, Helmy,Tarek, Althouse,AndrewD, Thomas,StephenB, Brooks,MariaMori, BARI2DStudyGroup]
通讯作者: BARI2DStudyGroup
Relation of severe coronary artery narrowing to insulin or thiazolidinedione use in patients with type 2 diabetes mellitus (from the Bypass Angioplasty Revascularization Investigation 2 Diabetes Study).
在2型糖尿病患者中使用胰岛素或噻唑烷二酮使用的严重冠状动脉的关系(来自旁路血管成形术血管血运重组研究2糖尿病研究)。
DOI: 10.1016/j.amjcard.2009.02.046
发表时间: 2009-07-01
期刊: AMERICAN JOURNAL OF CARDIOLOGY
影响因子: 2.8
作者: [Pop-Busui, Rodica, Lombardero, Manuel, Lavis, Victor, Forker, Alan, Green, Jennifer, Korytkowski, Mary, Sobel, Burton E., Jones, Teresa L. Z.]
通讯作者: Jones, Teresa L. Z.
共 27 条
    BARI II GRANT PROPOSAL FOR ECG CORE LABORATORY
    • 批准号:
      7068505
    • 项目类别:
    • 资助金额:
      $16.81万
    • 财政年份:
      2000
    • 负责人:
      Bernard R Chaitman
    • 依托单位:
    BARI II GRANT PROPOSAL FOR ECG CORE LABORATORY
    • 批准号:
      6752809
    • 项目类别:
    • 资助金额:
      $17.22万
    • 财政年份:
      2000
    • 负责人:
      Bernard R Chaitman
    • 依托单位:
    BARI II GRANT PROPOSAL FOR ECG CORE LABORATORY
    • 批准号:
      6030941
    • 项目类别:
    • 资助金额:
      $15.68万
    • 财政年份:
      2000
    • 负责人:
      Bernard R Chaitman
    • 依托单位:
    BARI II GRANT PROPOSAL FOR ECG CORE LABORATORY
    • 批准号:
      6537499
    • 项目类别:
    • 资助金额:
      $24.95万
    • 财政年份:
      2000
    • 负责人:
      Bernard R Chaitman
    • 依托单位: