BIOMIMETIC HETEROGENEOUS CATALYSIS FOR ENANTIOSELECTIVE OXIDATIONS

拟议的研究将允许人员在最初的两年时间内在谢菲尔德和约克之间自由流动，尽管它的目的是将这一点扩大到长期的重点合作。总的目标是绿色和可持续的催化剂和方法，用于高附加值的有机分子的对映选择性氧化。该项目的最终目标将是以正相水或超临界二氧化碳为溶剂合成关键的有机环氧化物和氢氧化物。研究的初始阶段将确定适合于多孔催化剂载体和活性金属络合物的小规模和大规模合成的候选体系。这将涉及固体催化剂合成和表征方面的关键技能的转让，以及材料的中试规模准备，这将导致用于连续流动处理的微反应器系统的设计、建造和测试，包括使用LabVIEW软件实施控制程序。此外，我们将利用负载型催化剂的表面分析来探索反应机理和失活途径，以帮助开发下一代催化剂。这项工作最终将开发出一种环境友好、清洁和可持续的工艺，使用包括水和超临界二氧化碳在内的良性溶剂系统生产具有商业价值的化学产品。这些技术在商业意义上的实施将通过我们与Astra Zeneca Charnwood，过程研究和开发的合作进行评估。在研究计划的同时，这一学科跳跃将使我们能够在化学和化学工程之间的界面上开发新的教学资源。

The research proposed will allow free movement of personnel between Sheffield and York over an initial two-year period although it is intended to extend this into a long-term focussed collaboration. The general target is green and sustainable catalysts and processes for the enantioselective oxidation of organic molecules with high added value. The ultimate aim of this project will be to synthesise key organic epoxides and dihydroxides using either normal phase water or supercritical carbon dioxide as the solvent.The initial phase of the research will identify candidate systems for the small and large-scale synthesis of porous catalyst supports and active metal complexes. This will involve the transfer of key skills in solid catalyst synthesis and characterisation and the pilot plant scale preparation of materials This will lead on to the design, construction and testing of micro reactor systems for continuous flow processing, including the implementation of control procedures using LabView software. Furthermore, we will use surface analysis of the supported catalysts to probe reaction mechanisms and deactivation pathways in order to aid the development of next generation catalysts.The work culminates in the development of an environmentally friendly clean and sustainable process, employing benign solvent systems including water and supercritical carbon dioxide, for the production of commercially important chemical products. The implementation of these technologies in a commercial sense will be assessed through our association with Astra Zeneca Charnwood, Process Research and Development.In parallel to the research programme this discipline hop will allow us to develop new teaching resources at the interface between chemistry and chemical engineering.