Molecular Mechanisms of Lung Inflammation

描述(由申请人提供)： 该项目的目的是培养博士后研究人员(3名博士和3名医学博士)。培养技能，使他们能够成为成功的独立调查人员，临床研究企业的未来领导者，以及下一代生物医学科学家的导师。重点将是将免疫学、分子细胞生物学、基因组学和蛋白质组学之间的接口联系起来，以了解人类肺部疾病的病理生理学。NIH路线图计划最近强调了这一培训计划的必要性，呼吁建立跨学科研究团队，目的是重新设计临床研究企业。将特别重视培训调查人员使用多学科方法来解决与肺部疾病的起源和治疗有关的基本问题。我们的培训人员被刻意挑选，以提供跨越这一领域的广泛培训环境，包括分子遗传学、免疫细胞功能、功能基因组学、肺上皮细胞功能、细胞信号、自由基生物学、线粒体生物学以及肺和血管病理生理学。目的1.在分子生物学、免疫学、细胞信号转导、自由基生物学、蛋白质组学和功能基因组学方面提供足够的教学、互动和技术背景，使学员能够在这些学科之间轻松移动，并能够将他们的知识转化为对肺部疾病起源的进一步了解。目标2.制定一项创新计划，确保受训者迅速进入直接的动手实验室体验。目标3.让受训者沉浸在创造性和积极的研究环境中，确保他们获得成功和留住的可能性最大。此外，还将提供研究伦理和研究哲学方面的具体培训，目的是培养能够在最高水平的学术诚信下开展工作的科学家。目标4.制定长期计划，鼓励妇女和少数民族从事肺部科学和研究事业，更重要的是，在培训计划内建立足够的基础设施和支持系统，以确保有动力的受训者取得成功。

DESCRIPTION (provided by applicant): The purpose of this program is to train postdoctoral investigators (3 Ph.D. and 3 M.D.) to develop skills that will allow them to become successful independent investigators, future leaders in the clinical research enterprise and mentors for the next generation of biomedical scientists. The emphasis will be upon linking the interface between immunology, molecular cell biology, genomics, and proteomics to understand the pathophysiology of human pulmonary disease. The need for this training program was recently emphasized by the NIH Roadmap initiative, calling for building interdisciplinary research teams with the intent of re-engineering the clinical research enterprise. Particular emphasis will be placed upon training investigators to use multidisciplinary approaches in attacking fundamental problems related to origins and cures for lung disease. Our training faculty were purposefully selected to provide a wide range of training environments that cross this spectrum, including molecular genetics, immune cell function, functional genomics, lung epithelial cell function, cell signaling, free radical biology, mitochondrial biology, and lung and vascular pathophysiology. Objective 1. To provide sufficient didactic, interactive and technical background in molecular biology, immunology, cell signaling, free radical biology, proteomics, and functional genomics to allow trainees to be able to move easily between these disciplines and to be able to translate their knowledge into further understanding of the origins of pulmonary disease. Objective 2. To develop an innovative program which ensures that trainees move rapidly into direct hands-on laboratory experiences. Objective 3. To immerse the trainees in a creative and positive research environment, ensuring the greatest possibility for their success and retention. In addition, specific training will be provided in the ethics and philosophy of research with the intent of producing scientists who will operate at the highest levels of intellectual integrity. Objective 4. To develop long-range programs which encourage women and minorities to pursue careers in pulmonary science and research and more importantly to build sufficient infrastructure and support systems within the training program to ensure the success of the motivated trainee.