Health & Psychosocial Need: Children with Developmental Disorder in a Time of HIV

健康

• 批准号: 7490427
• 负责人: Leslie L. Davidson
• 金额: $ 49.92万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7490427
• 关键词: 6 year old; AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Address; Admission activity; Adolescence; Adult; Affect; Africa; African; Age; Alcohol abuse; Alcohol consumption; Alcohol or Other Drugs use; Alcohols; Ally; Anemia; Area; Attention; Behavioral; Benzene; Brain; Brain Diseases; Caregivers; Caring; Cessation of life; Characteristics; Child; Child Care; Child Development; Child Mental Health; Child health care; Childhood; Clothing; Cognitive; Cohort Studies; Collaborations; Communicable Diseases; Communities; Community Health; Conceptions; Condition; Crutches; Data; Databases; Day Care; Dental caries; Developed Countries; Developing Countries; Development; Developmental Delay Disorders; Developmental Disabilities; Diarrhea; Disabled Persons; Discipline of obstetrics; Disease; Economic Factors; Economics; Education; Educational process of instructing; Emotional; England; Ensure; Epidemic; Epidemiologic Studies; Ethnography; Exposure to; Failure; Family; Family Caregiver; Fees; Food; Funding; Future; Genes; Glass; Goals; Government; Grant; Growth; HIV; HIV Infections; HIV Seropositivity; Health; Health Professional; Health Services Accessibility; Health Status; Health education; Hearing Aids; High Prevalence; Home environment; Home visitation; House Call; Household; Housing; Human immunodeficiency virus test; Hypertension; Immunization; Improve Access; Infection; Interdisciplinary Study; International; Interruption; Intervention; Intervention Studies; Lead; Life; Life Cycle Stages; Light; Link; Marijuana; Measurement; Measures; Mediating; Mediator of activation protein; Medical; Medical Surveillance; Meningitis; Mental Depression; Mental Health; Mental Health Services; Methods; Micronutrients; Modeling; Monitor; Neonatal; Neurodevelopmental Disability; Neurodevelopmental Disorder; Numbers; Nutritional; Outcome; Parent-Child Relations; Parenting behavior; Parents; Perinatal; Perinatal Infection; Personal Satisfaction; Pharmaceutical Preparations; Pneumonia; Policies; Population; Population Study; Poverty; Pre-Eclampsia; Prevalence; Preventive; Primary Prevention; Primary Schools; Provider; Psychosocial Assessment and Care; Psychosocial Factor; Public Health Education; Public Health Students; Range; Rate; Rehabilitation therapy; Relative (related person); Research; Research Methodology; Research Personnel; Resources; Risk; Risk Behaviors; Risk Factors; Risk-Taking; Rural; Sampling; School-Age Population; Schools; Screening procedure; Seizures; Services; Smoking; Social Functioning; Social Welfare; Social support; Socioeconomic Status; South Africa; Staging; Stress; Students; Study Section; Substance abuse problem; Supplementation; Technology Transfer; Testing; Therapeutic Intervention; Time; Tobacco; Training; Translating; Trauma; Trust; United States; United States National Institutes of Health; Universities; Violence; Water; Work; Youth; addiction; affection; age group; aged; base; cognitive function; cohort; community intervention; congenital infection; contextual factors; design; developmental disease; developmentally disabled; disability; early childhood; experience; follow-up; improved; improved functioning; intervention program; loss of function; medical schools; multidisciplinary; nervous system development; neurodevelopment; nutrition; pediatric department; prenatal; prenatal risk factor; programs; psychosocial; resilience; social; social organization; socioeconomics; tertiary prevention; therapy design; transmission process; water quality

DESCRIPTION (provided by applicant): With the long term goal of intervening to promote better physical and psychosocial functioning of children in South Africa, this study will determine how the ability of children with neurodevelopmental disorders to function cognitively and socially is influenced by both health-related (HIV, anemia, other infection), contextual (socio-economic and environmental, access to care and therapeutic intervention) and psychosocial factors (caregiver characteristics including mental health and substance use, family functioning). Approximately 2000 5 and 6 year old children from a HIV prevalent area will be screened for disability and then assessed before school entry. They will be reassessed 24 months later after school entry. The study will offer HIV testing to children and caregivers and referral for treatment for all conditions identified. Many of these children live with parents who are ill or have parents who have died from AIDS. Additional challenges such as poverty, inadequate access to health care and to education are common; many other risks to child health and well-being, including inadequate nutrition, infection and trauma as well as caregiver depression and substance use affect many children. As a result, many children do not function at optimal levels, and are at risk for developmental disabilities. The study will investigate first cross sectionally and then longitudinally the relationships among neurodevelopmental disorders and the above mentioned risk factors including as outcomes, child cognitive and psychosocial functioning and in the longitudinal aim, school functioning .The study will address both cross sectional and longitudinal relationships, assessing the impact of referral, treatment and access to programs over time. Community ethnographic studies will be linked to the findings of the epidemiologic study to identify culturally appropriate interventions. We will identify factors open to intervention which are known to affect child risk and resilience and work with community leaders in a participatory approach to develop an effective community based intervention. In addition, training in research methods and enhancing research capacity will be one of the key aims of this research. This will involve training public health students, ethnography students, pediatric registrars, allied health professionals and community health workers in both field and classroom teaching and training. This will be managed in collaboration with the UKZN Fogarty Program, the Valley Trust, the Rehabilitation Unit and the Medical School at UKZN with assistance from the Columbia investigators

描述（申请人提供）：长期目标是干预以促进南非儿童更好的身体和心理社会功能，本研究将确定神经发育障碍儿童的认知和社会功能如何受到健康相关因素的影响。（艾滋病毒、贫血、其他感染），背景（社会经济和环境，获得护理和治疗干预的机会）和心理社会因素（护理人员的特点，包括心理健康和药物使用、家庭功能）。将对来自艾滋病毒流行地区的大约2 000名5岁和6岁儿童进行残疾筛查，然后在入学前进行评估。他们将在入学后24个月重新评估。这项研究将为儿童和照顾者提供艾滋病毒检测，并为所有确定的疾病提供治疗。这些儿童中有许多与患病的父母或死于艾滋病的父母生活在一起。其他挑战，如贫穷、获得保健和教育的机会不足也是常见的;许多儿童的健康和福祉面临其他风险，包括营养不足、感染和创伤以及照料者抑郁和吸毒。因此，许多儿童不能在最佳水平上发挥作用，并面临发育障碍的风险。该研究将首先横向调查，然后纵向调查神经发育障碍和上述风险因素之间的关系，包括作为结果，儿童认知和心理社会功能，并在纵向目标，学校功能。该研究将解决横向和纵向关系，评估转诊，治疗和访问程序随着时间的推移的影响。社区人种学研究将与流行病学研究的结果联系起来，以确定文化上适当的干预措施。我们将确定已知影响儿童风险和复原力的开放干预因素，并与社区领导人合作，以参与式方法制定有效的社区干预措施。此外，培训研究方法和提高研究能力将是这项研究的主要目标之一。这将涉及在实地和课堂教学和培训方面培训公共卫生学生、人种学学生、儿科登记员、专职卫生人员和社区卫生工作者。这将在哥伦比亚研究人员的协助下，与UKZN Fogarty项目、山谷信托基金会、康复单位和UKZN医学院合作管理