Immunology of Infectious Disease

描述（由申请人提供）：传染病和免疫学的研究是密切相关的。所有病原体都必须与宿主免疫反应相互作用并逃避宿主免疫反应，至少在一段时间内，以建立感染并引起疾病，免疫系统的存在主要是为了抵御入侵者，主要是微生物。因此，传染病的研究必须包括对宿主反应的理解，而免疫学的研究最终集中在检测和消除微生物病原体上。虽然这种相互作用似乎非常清楚，但在实践中，研究微生物的研究人员并不总是对免疫学有一个舒适的知识，反之亦然。这是在“传染病免疫学”培训计划的目标，培养未来的科学家感到舒适，在这两个世界，理解和应用微生物学和免疫学的危险和新兴病原体的研究，并采用研究策略，桥梁两个领域。特别是，这对于研究有可能用于生物战的微生物制剂的免疫学和发病机理将是重要的。下一代科学家必须准备好应对自然出现或在生物防御背景下出现的新兴病原体。该培训计划旨在吸引最优秀的学生和博士后研究员在这一领域进行培训，将跨学科生物医学研究生课程，分子病毒学和微生物学和免疫学中的两个课程联系起来。培训教师包括来自医学院、公共卫生研究生院和文科和理科本科学院许多系的科学家。培训将利用我们现有的研究生课程的结构，以及（课程，研讨会系列，和杂志俱乐部已经到位。此外，正在为研究新出现的病原体和生物恐怖制剂而设计新的课程和系列研讨会。这个培训项目与匹兹堡大学生物防御研究的不断发展的重点相结合。我们的目标是培养科学家从微生物和免疫学的角度研究传染病，并以创造性和实用性来解决新兴或生物战剂的问题，以开发新颖有效的治疗和预防策略。

DESCRIPTION (provided by applicant): The study of infectious diseases and immunology is intimately linked. All pathogens must interact with and evade the host immune response, at least for some period of time, to establish infection and cause disease, the immune system exists primarily to fend off intruders, primarily microbes. Therefore, the study of (infectious disease must include an understanding of the host responses, and the study of immunology ultimately centers on detecting and eliminating microbial agents. Although this interaction seems very clear, in practice researchers studying microbes have not always had a comfortable knowledge of immunology, and vice versa. It is the goal of this Training Program in "Immunology of Infectious Disease" to train future scientists to feel comfortable in both worlds, to understand and apply microbiology and immunology to the study of dangerous and emerging pathogens, and to employ research strategies that bridge both fields. In particular, this will be important for research on the immunology and pathogenesis of microbial agents that have the potential to be used in biological warfare. The next generation of scientists must be ready to address emerging and new pathogens as they arise, either naturally or in the context of biodefense. This Training Program is designed to attract the very best students and post-doctoral fellows for training in this area, linking two programs within the Interdisciplinary Biomedical Graduate Program, Molecular Virology and Microbiology and Immunology. The training faculty includes scientists from numerous departments in the School of Medicine, Graduate School of Public Health, and the Undergraduate Faculty of Arts and (Sciences. Training will take advantage of the structure of our existing graduate programs, as well as (courses, seminar series, and journal clubs already in place. In addition, new courses and seminar series designed for study of emerging pathogens and bioterror agents are in development. This training program interfaces well with the evolving emphasis on biodefense research here at the University of Pittsburgh. Our goal is to train scientists to study infectious diseases from both the microbiologic and immunologic perspectives, and to approach problems of emerging or biowarfare agents with creativity and practicality for development of novel and effective treatment and prevention strategies.