Cellular and Molecular Microbiology Training Program

细胞和分子微生物学培训计划

• 批准号: 7491744
• 负责人: Jack J Hawiger
• 金额: $ 17.71万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-30 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7491744
• 关键词: Microbiology; Molecular; Training Programs

DESCRIPTION (provided by applicant): This renewal application seeks support for continuation of a unique and timely research training program in Cellular and Molecular Microbiology conducted by an interdisciplinary group of faculty investigators at Vanderbilt University (VU) and Meharry Medical College (MMC). These investigators represent the coalescing disciplines of microbial pathogenesis and cell biology which evolve into the growing field of cellular microbiology. The Program offers trainees with research opportunities for new discoveries in the study of the pathogen-host interactions relevant to biodefense and other microbes that cause human diseases, including Severe Acute Respiratory Syndrome (SARS). The training faculty at VU and MMC has demonstrated a highly effective commitment to 13 predoctoral students supported by this Program. The innovative features of this program are vested in state-of-the-science cell biology approaches as applied to the study of organisms important for human pathogenesis in the following areas: (i) Host-Cell Interaction with Potential Bioweapon Agents and Development of Countermeasures; (ii) Virus-Cell Interactions; (iii) Microbial Adhesion to Cellular Receptors; (iv) Microbial Cues for Cytoskeleton, Cytokinesis and Cell Cycle; (v) Endosomal-Lysosomal Pathway of Microbial Internalization and Processing; (vi) Signal Transduction and Gene Transcription Evoked by Pathogens; (vii) Nuclear Import and Export; (viii) RNA and DNA Binding Proteins in Pathogen-Host Interaction; (ix) ER and Golgi Pathways for Microbial Peptides, Glycolipids, and Glycoproteins; and (x) Mitochondria and Microbial Strategy for Survival. This well-defined Program recruits predoctoral trainees with explicit interests in cellular microbiology of pathogen-host interactions from a pool of graduate and MD/PhD students who matriculated to VU and MMC and have indicated microbiology, virology, immunology, and/or molecular cell biology as their area(s) of interest. These students are offered the Program's flagship course, "Cellular Microbiology of the Pathogen-Host Interaction." The competing application also proposes inclusion of select summer undergraduate trainees, with special emphasis on underrepresented minorities, who seek a career in the biomedical sciences. The Program is based on a stringent selection and monitoring by the Steering Committee which promotes vigorous mentorship and scientific interactions between participating laboratories and early career counseling. The Program's overall mission is to interface trainees with a highly interactive group of VU/MMC faculty and to foster the career development of new pioneers in the field of cellular microbiology of the pathogen-host interactions.

描述（由申请人提供）：此续期申请寻求对范德比尔特大学（VU）和梅哈里医学院（MMC）跨学科研究人员小组在细胞和分子微生物学方面进行的独特和及时的研究培训计划的继续支持。这些研究人员代表了微生物发病机制和细胞生物学的融合学科，这些学科发展成为细胞微生物学的发展领域。该方案为受训者提供研究机会，以研究与生物防御和引起包括严重急性呼吸系统综合症（SARS）在内的人类疾病的其他微生物有关的病原体-宿主相互作用的新发现。VU和MMC的培训教师已经证明了对13名受该计划支持的博士生的高效承诺。该计划的创新特点是将最先进的细胞生物学方法应用于以下领域对人类发病机制重要的生物体的研究：(i)宿主-细胞与潜在生物武器制剂的相互作用和对策的开发；㈡病毒-细胞相互作用；(3)微生物