Immunologic/Genetic Mechanisms in Rheumatic Diseases

风湿性疾病的免疫/遗传机制

• 批准号: 7417752
• 负责人: WESTLEY H REEVES
• 金额: $ 18.6万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-05-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7417752
• 关键词: Genetic; Immunologics; Rheumatism

DESCRIPTION (provided by applicant): Postgraduate Rheumatology training programs are devoted largely to training young physicians in the clinical aspects of rheumatic diseases. There are only a handful of strong basic-science-oriented programs that consistently have produced high quality graduates equipped by their training experience for an academic career in teaching and research directed at key problems related to the connective tissue diseases. There is a particular need for biomedical scientists trained in disease-related clinical research. This goal of this research training program, now in its fifth year of funding, is to provide a broad investigational experience in laboratory and/or non-laboratory research related to the study of rheumatic diseases. The training program focuses on the immunology and genetics of autoimmunity, vasculitis, and the connective tissue diseases. Formal curricula as well as research focus groups provide a structure for the program. The program is designed to provide cross-fertilization between individuals with a basic science background and those with clinical training. Patient- and disease-oriented research is emphasized. The training of M.D. postdoctoral fellows who plan careers in academic rheumatology is an important objective. As in the past, both pre-doctoral candidates and postdoctoral fellows will select mentors from a diverse clinical and basic science faculty. Infrastructure for carrying out clinical research has been expanded considerably during the past three years and a strong link has been forged with the University's General Clinical Research Center. The ability to carry out patient-based research is enhanced by a large patient base and ongoing active research in systemic lupus erythematosus, Sjogren's syndrome, type I diabetes, and other autoimmune diseases along with financial support for these programs through the Centers for Autoimmune Diseases and Immunology & Transplantation. The training is largely preceptorial, with more than 75% of the trainee's time devoted to independent research activities. Ongoing animal and human biomedical research addresses many issues relevant to autoimmunity, vasculitis/vascular biology, arthritis, therapeutics (gene and stem cell therapy), and other forms of immunological disease, encompassing the fields of immunology, genetics, cell biology, biochemistry, epidemiology, and biostatistics. Faculty includes individuals from the basic sciences as well as clinical departments.

描述(由申请人提供)： 风湿学研究生培训计划主要致力于培训年轻医生在风湿病的临床方面。只有少数几个强大的以基础科学为导向的项目一直培养出高质量的毕业生，他们的培训经验为从事与结缔组织疾病相关的关键问题的教学和研究的学术生涯做好了准备。尤其需要受过疾病相关临床研究培训的生物医学科学家。这项研究培训计划的目标是在实验室和/或与风湿性疾病研究相关的非实验室研究中提供广泛的研究经验。培训计划侧重于自身免疫学、血管炎和结缔组织疾病的免疫学和遗传学。正规课程和研究重点小组为该计划提供了一个结构。该计划旨在为具有基础科学背景的个人和接受过临床培训的个人提供交叉受精。强调以患者和疾病为导向的研究。在学术风湿学领域规划职业生涯的医学博士后研究员的培训是一个重要目标。与过去一样，博士后候选人和博士后研究员都将从不同的临床和基础科学教职员工中挑选导师。在过去三年中，开展临床研究的基础设施得到了相当大的扩展，并与该大学的综合临床研究中心建立了牢固的联系。通过对系统性红斑狼疮、干燥综合征、I型糖尿病和其他自身免疫性疾病的大量患者基础和持续的积极研究，以及通过自身免疫性疾病和免疫学与移植中心对这些项目的财政支持，加强了开展以患者为基础的研究的能力。培训在很大程度上是指导性的，学员75%以上的时间用于独立研究活动。正在进行的动物和人类生物医学研究涉及许多与自身免疫、血管炎/血管生物学、关节炎、治疗学(基因和干细胞疗法)和其他形式的免疫疾病有关的问题，包括免疫学、遗传学、细胞生物学、生物化学、流行病学和生物统计学等领域。教师包括来自基础科学和临床科室的个人。