Occupational risk factors for NHL and NHL subtypes: an InterLymph-based analysis

描述（由申请人提供）： 非霍奇金淋巴瘤（NHL）的发病率和死亡率在过去的二十年中一直在全球范围内增加。这种趋势的原因是未知的，目前对NHL的病因学的知识仍然很差。针对职业风险因素的研究提出了有用的病因学假设（如农药和溶剂暴露），但研究结果并不一致。我们将对来自北美、欧洲和澳大利亚的9项NHL病例对照研究进行汇总分析，以研究不同人群中职业危险因素与NHL之间的关联。具体而言，我们将：“目标1 -调查以前发现的与NHL有关的职业危险因素”，使用统一定义的职业暴露指标。我们还将：“目标2 -通过NHL亚型评估风险”，使用基于组织学确诊的标准NHL分类。汇总在11个国家进行的9项病例对照研究的数据，将产生9，490例病例和10，971例对照的研究人群，代表迄今为止最大的NHL研究。我们将开发职业和职业暴露的统一定义的变量，特别是工作中的农药，溶剂和传染性病原体，并通过非条件logistic回归研究职业和职业暴露与NHL和NHL亚型之间的关联。病例对照研究是InterLymph联盟的一部分，该联盟的建立是为了促进NHL流行病学研究之间的合作。InterLymph协作具有特殊的优势，纳入研究的病例已被归类为标准方案，从而使所有研究中的NHL亚型有效分组。这些研究包括人群或医院对照，关于职业危险因素和潜在混杂因素的信息已经收集并计算机化。这项由国际专家合作团队进行的大型研究将提供足够的研究力量来实现概述的目标，并有助于NHL病因学的知识。

DESCRIPTION (provided by applicant): Non-Hodgkin lymphoma (NHL) incidence and mortality have been increasing worldwide during the last two decades. The causes of this trend are unknown, and the current knowledge on the etiology of NHL is still poor. Studies focusing on occupational risk factors have generated useful etiologic hypotheses (e.g. pesticides and solvents exposure), but study findings have not been consistent. We will conduct a pooled analysis of 9 NHL case-control studies from North America, Europe, and Australia, to study the association between occupational risk factors and NHL, in different populations. Specifically, we will: "Aim 1 - investigate occupational risk factors previously found to be associated with NHL", using uniformly defined indicators for occupational exposure. We will also: "Aim 2 - evaluate risk by NHL subtype", using a standard NHL classification based upon histologically confirmed diagnoses. Pooling of the data from the 9 case-control studies conducted in 11 countries, will yield a study population of 9,490 cases and 10,971 controls, representing the largest NHL study to date. We will develop uniformly defined variables for occupations and occupational exposures, particularly pesticides, solvents, and infectious agents at work and study the association between occupation and occupational exposure and NHL and NHL subtypes through unconditional logistic regression. The case-control studies are part of the InterLymph consortium, which was established to facilitate the cooperation between epidemiological studies of NHL. The InterLymph collaboration has as particular strength that the cases of included studies have been classified into a standard scheme, thus enabling valid grouping of NHL suptypes over all studies. The studies include population or hospital controls, for which information on occupational risk factors and potential confounders has already been collected and computerized. This large study conducted by an international team of expert collaborators will provide sufficient study power to reach the outlined aims and contribute to the knowledge of the etiology of NHL.