Pilot for a Multicenter Case-Control Study of Pancreatic Cancer in a High Risk r*

描述(申请人提供)：在国际层面上，胰腺癌的发病率最高的是美国黑人和中欧，特别是捷克共和国和斯洛伐克的高加索人口。这种高发病率的原因尚不清楚。我们将在捷克共和国和斯洛伐克高危地区的5个中心进行胰腺癌多中心病例对照研究试点，以调查已有和潜在的危险因素的作用，并为未来的分子和遗传流行病学研究建立生物信息库。这项试点研究将建立在以前在这些中心成功开展的关于肺癌和肾癌的大型病例对照研究的基础上。我们拟议的研究将重点关注生活方式和职业风险因素的作用，包括烟草和酒精，以及接触特定金属、溶剂和杀虫剂。它还将纳入以下重要特征：超快的病例识别(即在初步诊断的几周内识别和约谈病例)；基于人群的病例识别(即试图招募发生在特定地理区域的所有病例)和招募人口控制人员，以及两者的高应答率；广泛收集生物样本，包括血液样本、活淋巴细胞、胰液和肿瘤组织。长期目标是为该地区基于人群的病例对照研究奠定基础，该研究将与美国和其他地方的其他类似倡议合作进行，并为未来的胰腺癌研究联盟做出贡献。与公共卫生相关：胰腺癌的病因在很大程度上仍不清楚。在这一高危人群中进行胰腺癌的初步研究是进行全面研究之前的必要步骤。一项全面研究的结果有可能确定胰腺癌的重要生活方式和职业风险因素，并为未来预防胰腺癌的努力提供信息。

DESCRIPTION (provided by applicant): On an international level, the highest incidence rates for pancreatic cancer occur among US blacks and among Caucasian populations in Central Europe, in particular in Czech Republic and Slovakia. The reason for this high incidence is not known. We will conduct a pilot for a multicentre case-control study of pancreatic cancer in 5 centers within the high risk region of Czech Republic and Slovakia in order to investigate the role of established and potential risk factors, as well as to generate a biorepository for future molecular and genetic epidemiology studies. This pilot study will build on previous large case- control studies that were successfully conducted in these centres on lung and kidney cancer. Our proposed study will have a strong focus on the role of lifestyle and occupational risk factors including tobacco and alcohol, as well as exposure to specific metals, solvents and pesticides. It will also incorporate the following important characteristics: Ultra rapid case identification (i.e. identify and interview cases within weeks of initial diagnosis); Population based case identification (i.e. try to recruit all cases occurring in a particular geographical region) and recruitment of population controls, as well as a high response rate for both; Extensive collection of biological samples including blood samples, viable lymphocytes, pancreatic juice and tumor tissue. The long term aim is to establish the foundation for a population based case-control study in this region, which will be conducted in collaboration with other similar initiatives in the US and elsewhere, and contribute to any future consortium of pancreatic cancer studies. Public health relevance: The causes of pancreatic cancer remain largely unknown. This pilot study of pancreatic cancer in this high risk population is a necessary step before a full study can be undertaken. The results of a full study have the potential to identify important lifestyle and occupational risk factors for pancreatic cancer and inform future prevention efforts against pancreatic cancer.