Lipid Transport-Connecting Fundamental Membrane Assembly To Human Disease

摘要：本申请是为了支持第一次专注于细胞脂质转运及其与人类遗传疾病的关系的国际会议。会议将为该学科的最新研究提供一个论坛，由于多种真核生物脂质转运的生物化学，遗传学和基因组学的进展，该学科目前正在迅速扩大。会议将于2008年10月29日至11月2日召开；在坎莫尔，AB，加拿大。会议的参与者将是主要科学家，他们的重点是细胞内的脂质转运过程，以及这些过程与细胞病理学和人类疾病的关系。除了受邀的演讲者外，与会者还将包括在会议主题领域有积极研究计划的资深科学家，以及来自这些实验室的研究生和博士后研究员。鼓励女性和少数族裔科学家参加这次会议，25%的受邀演讲者是女性。在海报会议期间，非受邀演讲者的与会者将有充足的机会展示作品，以及与受邀演讲者演讲混合的简短口头报告。会议的目的是宣传细胞脂质转运主题的最新进展，并批判性地讨论疾病过程如何由分子缺陷引起。将要讨论的主题包括：1)ABC转运蛋白及其在人类和小鼠眼睛、肺部和肝脏疾病中的作用，以及原核生物内毒素的生物合成；2) p型atp酶及其在真核生物基本膜组装过程中的作用，以及人类肝内胆汁淤积的发生；3)脂质识别蛋白在细胞生长发育和类固醇激素产生中的重要性；4) Niemann Pick C家族蛋白在控制肠和脑脂质转运过程中的作用及其与特定疾病过程的关系。7. 项目说明

DESCRIPTION (provided by applicant): Abstract Summary: This application is for support of the first international meeting focused solely upon the topic of cellular lipid transport and its relationship to human genetic diseases. The meeting will provide a forum for the latest research in this discipline, which is now rapidly expanding as a consequence of advances in the biochemistry, genetics and genomics of lipid transport in multiple eukaryotes. The meeting will convene from Oct 29-Nov 2, 2008; in Canmore, AB, Canada. The participants in the meeting will be leading scientists whose focus is upon lipid transport processes within cells, and the relationship of these processes to cellular pathology and human diseases. In addition to invited speakers, attendees will include senior scientists with active research programs in the topic areas of the conference, and graduate students and postdoctoral fellows from these laboratories. Women and minority scientists are encouraged to participate in this meeting and 25% of the invited speakers are women. There will be ample opportunities for presentation of work by attendees who are not invited speakers, during poster sessions, and short oral presentations, which are mixed with invited speaker presentations. The objectives of the meeting are to publicize the latest advances in the topics of cellular lipid transport and critically discuss how disease processes result from molecular defects. The topics to be addressed include: 1) ABC transporters and their roles in eye, lung and liver disease in humans and mice, and the biosynthesis of endotoxins in prokaryotes; 2) P-type ATPases and their role in fundamental membrane assembly processes of eukaryotes, and the development of intrahepatic cholestasis in humans; 3) the importance of lipid recognition proteins in cell growth and development and production of steroid hormones; and 4) the role of Niemann Pick C family proteins in controlling lipid transport processes in the intestine and brain and their relationship to specific disease processes. 7. Project Narrative N/A