Extra-Nuclear Steroid Receptors: Integration with Multiple Signaling Pathways

核外类固醇受体：与多种信号通路的整合

• 批准号: 7538897
• 负责人: STEPHEN R. HAMMES
• 金额: $ 1.5万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7538897
• 关键词: Adrenal gland hypofunction; Apoptosis; Award; Biological Process; Cell Nucleus; Cell membrane; Clinical; Collaborations; Communities; Data; Development; Fostering; Genetic Transcription; Genomics; Germ Cells; Glucocorticoids; Hormones; International; Link; Mediating; Membrane; Neoplastic Processes; Neurons; Nuclear; Nuclear Receptors; Pathway interactions; Patients; Phosphorylation; Phosphotransferases; Physiology; Process; Purpose; Range; Receptor Signaling; Regulation; Research; Research Personnel; Services; Signal Pathway; Signal Transduction; Steroid Receptors; Steroids; Thinking; Travel; Work; abstracting; angiogenesis; career; concept; inhibitor/antagonist; interest; non-genomic; novel; posters; practical application; professor; protein expression; receptor function; symposium; therapeutic target; unpublished works

DESCRIPTION (provided by applicant): Steroid-mediated processes have traditionally been thought to be regulated by changes in nuclear receptor transcriptional activity. However, clinical clues have suggested that steroids must also signal independent of transcription. For example, glucocorticoid treatment of patients with adrenal insufficiency results in symptomatic relief within minutes - much too rapidly to involve changes in transcription and subsequent protein expression. Accordingly, recent studies have detected classical steroid receptors at the plasma membrane, where they signal through activation of extra-nuclear, transcription-independent signaling pathways. While the importance of these effects was first met with healthy skepticism, the field of extra-nuclear steroid receptor signaling has exploded over the past ten years. Nongenomic actions of steroids are now accepted to participate in regulating many important biological processes, including proliferation, apoptosis, angiogenesis, neuronal signaling, and germ cell development. In addition, membrane-initiated and nuclear steroid receptor signaling have been shown to work in synergy such that membrane-initiated steroid signaling leads to enhanced transcription by classical steroid receptors. Finally, the study of steroid-triggered, transcription-independent, pathways has revealed novel signaling mechanisms that are currently being targeted to suppress hormone-dependent neoplastic processes. The purpose of this FASEB-sponsored conference is to bring together investigators studying both transcription-independent and -dependent steroid signaling in an effort to foster cross talk and collaboration, as well as to further unify the field of steroid signaling. The three aims of this conference are: 1) To review exciting new discoveries in the fields of both extra-nuclear and transcriptional steroid signaling; 2) To provide a venue for young investigators to present their work and interact with established leaders in the field of steroid signaling; and 3) Discuss the important translational implications of steroid signaling research.

描述(由申请人提供)： 类固醇介导的过程传统上被认为是通过核受体转录活性的变化来调节的。然而，临床线索表明，类固醇也必须发出不依赖于转录的信号。例如，肾上腺功能不全患者的糖皮质激素治疗在几分钟内就能缓解症状--太快了，不能涉及转录和随后的蛋白表达的变化。因此，最近的研究已经在质膜上检测到经典的类固醇受体，在那里它们通过激活核外、转录无关的信号通路来传递信号。虽然这些效应的重要性最初受到了健康的怀疑，但在过去的十年里，核外类固醇受体信号领域出现了爆炸性的增长。类固醇的非基因组作用被认为参与调控许多重要的生物学过程，包括增殖、凋亡、血管生成、神经元信号转导和生殖细胞发育。此外，膜启动的类固醇受体信号和核内的类固醇受体信号被证明是协同作用的，膜启动的类固醇信号导致经典类固醇受体的转录增强。最后，对类固醇触发的、转录无关的通路的研究揭示了新的信号机制，目前目标是抑制激素依赖的肿瘤过程。这次由FASE B赞助的会议的目的是将研究转录非依赖和依赖的类固醇信号的研究人员聚集在一起，努力促进串扰和合作，以及进一步统一类固醇信号领域。这次会议的三个目的是：1)回顾在核外和转录类固醇信号领域令人兴奋的新发现；2)为年轻的研究人员提供一个展示他们的工作并与类固醇信号领域的知名领导者互动的场所；以及3)讨论类固醇信号研究的重要翻译含义。