2008 Bioanalytical Sensors Gordon Research Conference

描述(由申请者提供)：本次拨款申请寻求对将于2008年6月29日至7月4日在国际扶轮社史密斯菲尔德的布莱恩特大学举行的第13届戈登生物分析传感器研究会议及其相关的戈登-凯南研究生研究研讨会(GRS)的部分支持。本次会议的长期目标是产生新的想法和合作，通过向与会者通报系统和材料开发、系统集成和自动化以及相关支持技术的最新研究，可能导致为未来的诊断平台改进仪器和材料。这次会议的具体目的是作为一个渠道，讨论生物化学、生物、化学、工程、医学和物理学中应用于生物分析传感器的开发和应用的未发表数据。这一目标将通过与会者积极参加两次海报会议、非正式讨论和9次口头会议来实现，28位发言者和9位讨论带头人。这里讨论的数据将涵盖不同的领域，并将涉及以下主题：1)使用标准抗体和核酸探针的替代方案进行分子识别；2)将磁性从样品分离转移到信号转导；3)光学、电化学和机械检测的最新进展；4)实际应用和活体传感；以及5)支持/使能技术。具体主题将包括(但不限于)基于单分子的探针、细胞内传感、具有增强的光学或电子性能的生物材料、纳米颗粒、生物兼容性和生物/非生物界面、小型化和自动化，以及复杂基质中的多路检测。这次会议及其相关的GRS的意义在于不断推进最先进的材料、方法和 用于快速测量具有临床意义的靶点的仪器。此外，通过将不同的参与者群体聚集在一起，形成的跨学科合作对于弥合现有和未来生物分析传感器的生物和物理方面的差距至关重要。这次会议与公共卫生高度相关，因为这里讨论的技术和未来的技术可以应用于诊断、生理监测、治疗效果的评估、潜在的预防措施以及对疾病原因的基础研究。 公共卫生相关声明(由申请者提供)：生物分析传感器戈登研究会议及其相关的GRS将继续推进材料、方法和仪器的最先进水平，以快速测量具有临床意义的目标。这次会议与公共卫生高度相关，因为这里讨论的技术和从这次会议衍生的未来技术可以应用于诊断、生理监测、 评估治疗效果、潜在的预防和对疾病原因的基础研究。

DESCRIPTION (provided by the applicant): This grant application seeks partial support for the 13th Gordon Research Conference on Bio-analytical Sensors, to be held at Bryant University, Smithfield, RI 29 June - 4 July 2008, and its associated Gordon-Kenan Graduate Research Seminar (GRS). The long term goal of this conference is to generate new ideas and collaborations that may lead to improved instrumentation and materials for future diagnostic platforms by informing participants of the latest research in systems and materials development, systems integration and automation, and relevant supporting technologies. This conference's specific aim is to serve as a conduit for discussions of unpublished data in biochemistry, biology, chemistry, engineering, medicine, and physics as they apply to development and application of bio-analytical sensors. This aim will be achieved through active participation of attendees in two poster sessions, informal discussions, and 9 oral sessions, with 28 speakers and 9 discussion leaders. The data discussed here will encompass diverse fields and will address the following themes: 1) molecular recognition using alternatives to standard antibodies and nucleic acid probes, 2) moving magnetic properties from sample separation to signal transduction, 3) recent advances in optical, electrochemical, and mechanical detection, 4) real-world applications and in vivo sensing, and 5) supporting/enabling technologies. Specific topics will include (but are not limited to) single molecule-based probes, intracellular sensing, biomaterials with enhanced optical or electronic properties, nanoparticles, biocompatibility and the biological/non-biological interface, miniaturization and automation, and multiplexed detection in complex matrices. The significance of this conference and its associated GRS is the continued advancement of state-of-the-art materials, methods, and instrumentation for rapid measurement of targets of clinical significance. Furthermore, by bringing together a diverse group of participants, the cross-disciplinary collaborations formed will be critical to bridge the gap between the biological and physical aspects of existing and future bioanalytical sensors. This conference is highly relevant to public health in that the technologies discussed here and future technologies derived thereof can be applied to diagnostics, physiological monitoring, assessment of treatment efficacy, potential preventative measures, and basic research into the cause of disease. PUBLIC HEALTH RELEVANCE STATEMENT (provided by applicant): The Bioanalytical Sensors Gordon Research Conference and its associated GRS will continue to advance the state-of-the-art in materials, methods, and instrumentation for rapid measurement of targets of clinical significance. This conference is highly relevant to public health in that the technologies discussed here and future technologies derived from this conference can be applied to diagnostics, physiological monitoring, assessment of treatment efficacy, potential prevention, and basic research into the cause of disease.