Fogarty International Research Collaboration Award

描述（由申请人提供）：本FIRCA申请描述了一个目前资助的NIH项目之间的拟议合作，该项目名为“墨西哥裔美国老年人的残疾过程”（2 R 01 AG 017638，K。Ottenbacher，PI）和哥伦比亚波哥大Pontifica Universidad Javeriana的Institute de Envejecimiento（老龄化研究所）（卡洛斯卡诺，医学博士，合作研究将使用两个现有的数据库-西班牙裔老年人既定人口流行病学研究和拉丁美洲和加勒比地区健康、福祉和老龄化SABE项目-检查拉丁美洲老年人的残疾过程。建议FIRCA研究的具体目标是：1。比较两个大型拉丁裔老年人人群样本中虚弱的发生率：西班牙裔EPESE和SABE研究。2.确定心理健康功能水平（认知和抑郁症状）是否可用于识别西班牙裔EPESE和SABE数据库中有发生虚弱风险的拉丁裔老年人。3.检查虚弱和健康结果（如残疾，福尔斯和住院治疗）之间的关联是否受到拉丁美洲老年人心理健康功能（认知和抑郁症状）水平的调节（西班牙裔EPESE和SABE数据库）。这些具体目标是母基金研究目标的直接延伸，并以两种重要方式扩展了NIH资助的研究。首先，目标是扩大残疾和脆弱的研究，包括一个代表美国以外的拉丁美洲人口的数据库（SABE）。其次，拟议的研究将提供有关来自不同国家和文化的拉丁美洲老年人样本中认知功能与虚弱/残疾之间关系的新信息。美国的研究小组有一个涉及拉丁美洲老年人的合作研究的既定记录。PI是该大学泛美卫生组织/世卫组织老龄与健康合作中心的主任，以前曾与哥伦比亚的研究人员合作。

DESCRIPTION (provided by applicant): This FIRCA application describes a proposed collaboration between a currently funded NIH project titled, "Disablement Process in Mexican American Older Adults" (2R01 AG017638, K. Ottenbacher, PI), and the Institute de Envejecimiento (Institute on Aging) at the Pontifica Universidad Javeriana in Bogota, Columbia (Carlos Cano, M.D., Director) The collaborative research will examine the disablement process in Latino older adults using two existing databases - the Hispanic Established Populations Epidemiologic Study of the Elderly (Hispanic EPESE) and the Health, Well-Being and Aging in Latin America and the Caribbean (Salud, Bienestar y Envejecimiento) SABE project. The specific aims for the proposed FIRCA research are to: 1. Compare the incidence of frailty in two large population-based samples of Latino older adults: the Hispanic EPESE and the SABE study. 2. Determine whether level of mental health function (cognition and depressive symptoms) can be used to identify Latino older adults at risk of developing frailty in the Hispanic EPESE and SABE databases. 3. Examine whether associations between frailty and health outcomes (such as disability, falls, and hospitalization) are moderated by level of mental health function (cognition and depressive symptoms) in Latino older adults (Hispanic EPESE and SABE databases). These specific aims are a direct extension of the research aims of the parent grant and extend the NIH funded research in two important ways. First, the aims expand the study of disability and frailty to include a database representing Latin American populations outside of the U.S. (SABE). Second, the proposed research will provide new information regarding the relationship between cognitive function and frailty/disability in samples of Latin American older adults from different countries and cultures. The U.S. based research team has an established record of collaborative research involving Latin American older adults. The PI is director of the university's PAHO/WHO Collaborating Center on Aging and Health and has previous experience working with investigators from Columbia.