CLINICAL TRIAL: RISPERIDONE AND BEHAVIOR THERAPY IN CHILDREN WITH PDD

临床试验：PDD 儿童的利培酮和行为疗法

• 批准号: 7718622
• 负责人: MICHAEL George AMAN
• 金额: $ 0.94万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-12-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7718622
• 关键词: Adaptive Behaviors; Aggressive behavior; Behavior Therapy; Child; Clinical Trials; Compliant Behaviors; Computer Retrieval of Information on Scientific Projects Database; Daily; Funding; Grant; Institution; Life; Measures; Parents; Pharmaceutical Preparations; Randomized Controlled Clinical Trials; Rate; Relapse; Research; Research Personnel; Resources; Risperidone; Self-Injurious Behavior; Source; Training; United States National Institutes of Health; Week; discontinuation trial; follow-up; skills; treatment effect

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. 1) to compare the benefits of risperidone only to risperidone + parent management training (PMT) on a measure of non-compliant behavior in children with PDD accompanied by tantrums, aggression, and/or self injury ("high irritability") in a 24-week randomized trial. 2) to compare the benefits of risperidone only to risperidone + PMT on adaptive behavior (daily living skills) in children with PDD and high irritability in a 24-week randomized trial. 3) to compare the rate of relapse when the medication is gradually withdrawn in a 10-week discontinuation trial in children treated successfully for up to 24 weeks with medication only or medication + PMT. 4) to evaluate enduring effects of these treatments at follow-up 20 months after study entry.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 1)在一项为期24周的随机试验中，比较单用利培酮与利培酮+父母管理训练（PMT）对伴有发脾气、攻击和/或自伤（“高度易怒”）的PDD儿童的不依从行为的影响。2)在一项为期24周的随机试验中，比较利培酮单独与利培酮+ PMT对PDD和高易怒儿童适应行为（日常生活技能）的益处。3)比较在一项为期10周的停药试验中，在仅接受药物治疗或接受药物治疗+ PMT成功治疗长达24周的儿童中逐渐停用药物时的复发率。4)在进入研究后20个月随访时评价这些治疗的持久效果。