PHARMACOKINETIC PILOT STUDY OF ZINC ABSORPTION

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Blood levels (plasma, RBC 5nucleotidase, and metallothionein) of zinc and 24-hr. urine excretion of zinc,considered together with clinical effect of a morning zinc supplement, suggest that children with attention-deficit/hyperactivity disorder (ADHD) may have a problem with zinc "wasting"; rapid excretion after absorption. As an exploratory study to determine whether this hypothesis should be tested by a more definitive larger zinc PK study, up to 4 children with ADHD and 2 normal control children will have a 9-hour PK study with the same dose of zinc (15 mg, slightly more than the RDI) used in the previous study. Blood (from indwelling catheter) and urine samples will be collected at 1, 2, 4, 6, 7, and 9 hours following supplement ingestion and a low-zinc breakfast. Data analysis and interpretation will be by visual inspection of graphed results over time. The hypothesis is that for the ADHD children but not normal controls, the blood level will rise the first few hours, then drop back to baseline by 5 hours, accompanied by a peak of urinary excretion.