Tolerance induction in a GalT-KO pig-to-baboon model through establishment of mix

通过混合建立 GalT-KO 猪狒狒模型的耐受性诱导

• 批准号: 7524169
• 负责人: DAVID H SACHS
• 金额: $ 0.51万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-20 至 2009-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7524169
• 关键词: Allogenic; Allografting; Animals; Antibodies; Antibody Formation; Antigens; Appearance; B-Lymphocytes; Blood specimen; Bone Marrow; Cell Surface Receptors; Cell Transplantation; Cell surface; Cells; Chimerism; Clinic; Clinical; Coagulation Process; Communicable Diseases; Complement; Condition; Data; Dose; Elements; Engraftment; Failure; Family suidae; Galactosyltransferases; Goals; Growth Factor; Hematopoietic; Hematopoietic stem cells; Human; Immune; Immune system; Immunity; Immunologics; Immunosuppression; Immunosuppressive Agents; In Vitro; Interleukin-3; Knock-out; Laboratories; Macaca fascicularis; Manuscripts; Mediating; Miniature Swine; Modality; Modeling; Modification; Natural Immunity; Natural Killer Cells; Organ; Organ Transplantation; Papio; Pathology; Pathway interactions; Peripheral; Phagocytosis; Pharmaceutical Preparations; Play; Polymerase Chain Reaction; Preparation; Prevention; Primates; Principal Investigator; Protocols documentation; Recombinants; Reporting; Rodent; Role; SCID Mice; Sampling Studies; Spleen; Standards of Weights and Measures; Stem cells; Sus scrofa; T-Cell Depletion; T-Lymphocyte; Testing; Therapeutic immunosuppression; Tissues; Transplantation; Transplantation Tolerance; Treatment Protocols; Xenograft procedure; absorption; conditioning; homologous recombination; human ITGA5 protein; irradiation; killings; knockout animal; macrophage; nonhuman primate; nuclear transfer; pre-clinical; prevent; programs; reconstitution; research study; response; success; thymus transplantation