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Tolerance induction in a GalT-KO pig-to-baboon model through establishment of mix

Tolerance induction in a GalT-KO pig-to-baboon model through establishment of mix
通过混合建立 GalT-KO 猪狒狒模型的耐受性诱导
批准号：
7524169
负责人：
DAVID H SACHS
金额：
$0.51万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
项目状态：
已结题
起止时间：
2007-07-20 至 2009-02-28
来源：
https://reporter.nih.gov/project-details/7524169
关键词：
AllogenicAllograftingAnimalsAntibodiesAntibody FormationAntigensAppearanceB-LymphocytesBlood specimenBone MarrowCell Surface ReceptorsCell TransplantationCell surfaceCellsChimerismClinicClinicalCoagulation ProcessCommunicable DiseasesComplementConditionDataDoseElementsEngraftmentFailureFamily suidaeGalactosyltransferasesGoalsGrowth FactorHematopoieticHematopoietic stem cellsHumanImmuneImmune systemImmunityImmunologicsImmunosuppressionImmunosuppressive AgentsIn VitroInterleukin-3Knock-outLaboratoriesMacaca fascicularisManuscriptsMediatingMiniature SwineModalityModelingModificationNatural ImmunityNatural Killer CellsOrganOrgan TransplantationPapioPathologyPathway interactionsPeripheralPhagocytosisPharmaceutical PreparationsPlayPolymerase Chain ReactionPreparationPreventionPrimatesPrincipal InvestigatorProtocols documentationRecombinantsReportingRodentRoleSCID MiceSampling StudiesSpleenStandards of Weights and MeasuresStem cellsSus scrofaT-Cell DepletionT-LymphocyteTestingTherapeutic immunosuppressionTissuesTransplantationTransplantation ToleranceTreatment ProtocolsXenograft procedureabsorptionconditioninghomologous recombinationhuman ITGA5 proteinirradiationkillingsknockout animalmacrophagenonhuman primatenuclear transferpre-clinicalpreventprogramsreconstitutionresearch studyresponsesuccessthymus transplantation

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Composite porcine islet-kidney xenotransplants to cure diabetes and renal failure
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Tolerance Induction in a GalT-KO Pig-to-Baboon Model Through Mixed Chimerism
  • 批准号：
    8190115
  • 项目类别：
  • 资助金额：
    $33.78万
  • 财政年份：
    2011
  • 负责人：
    DAVID H SACHS
  • 依托单位：
    MASSACHUSETTS GENERAL HOSPITAL
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