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MDMA Dependence and Discontinuation Syndrome

MDMA 依赖和停药综合症

基本信息

批准号：
7675099
负责人：
JOHN E. MENDELSON
金额：
$ 8.38万
依托单位：
CALIFORNIA PACIFIC MED CTR RES INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-07-01 至 2010-04-30
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): MDMA is one of the most widely abused drugs by adolescents and young adults. Recent studies suggest widespread MDMA dependence, with up to 48% of users diagnosed as dependent. These studies suggest that day-to-day problems relating to MDMA abuse and dependence may be more severe and prevalent than previously believed. Yet MDMA dependence has not been fully characterized, with signs, symptoms, risk and protective factors, and the natural history of MDMA dependence remaining largely unknown. Retrospective reports document high rates of appaxent withdrawal symptoms in MDMA users. It remains to be determined the extent to which symptoms are due to other drugs, sequelae of activities undertaken while under the influence of MDMA, reemergence of preexisting conditions, or represent a true MDMA discontinuation syndrome. We propose a series of controlled inpatient trials to characterize MDMA dependence and the MDMA-specific discontinuation syndrome. In the first experiment, MDMA users (80 dependent and 80 nondependent) will be hospitnlized and given placebo or a single nontoxic dose of MDMA in order to elicit a discontinuation syndrome. In the second experiment, 40 hospitalized dependent MDMA users will be given placebo or a single nontoxic dose of MDMA to relieve withdrawal following illicit use of MDMA. Stir-report, observer-rated, physiological, neurocognitive, hormonal, and behavioral measures will be made. Addiction to MDMA appears to be a serious risk of use; our studies will carefttlly define important clinical features of this emerging disorder.

描述（由申请人提供）：MDMA是青少年和年轻人最广泛滥用的药物之一。最近的研究表明，广泛的MDMA依赖，高达48%的用户被诊断为依赖。这些研究表明，与MDMA滥用和依赖有关的日常问题可能比以前认为的更为严重和普遍。然而，尚未充分描述MDMA依赖的特征，其体征、症状、风险和保护因素以及MDMA依赖的自然史在很大程度上仍然未知。回顾性报告记录了MDMA使用者中明显戒断症状的高发生率。尚待确定症状在多大程度上是由于其他药物、在MDMA影响下进行的活动的后遗症、原有疾病的复发或代表真正的MDMA停药综合征。我们提出了一系列对照住院试验，以描述MDMA依赖和MDMA特异性停药综合征。在第一个实验中，MDMA使用者（80名依赖者和80名非依赖者）将住院治疗，并给予安慰剂或单次无毒剂量的MDMA，以引起停药综合征。在第二个实验中，40名住院的MDMA依赖者将被给予安慰剂或单次无毒剂量的MDMA，以缓解非法使用MDMA后的戒断症状。将进行Stir报告、评分、生理、神经认知、激素和行为测量。MDMA成瘾似乎是一种严重的使用风险;我们的研究将仔细定义这种新兴疾病的重要临床特征。