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Pathogenesis And Immunology Of Animal And Human Retroviruses

Pathogenesis And Immunology Of Animal And Human Retroviruses
动物和人类逆转录病毒的发病机制和免疫学
批准号：
7592113
负责人：
Bruce Chesebro
金额：
$25.77万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/7592113
关键词：
Amino AcidsAnimalsBrain DiseasesCellsGoalsHIVHumanImmunologyInfectionLocationMusPathogenesisRetroviridaeRetroviridae InfectionsStructureVirusbasebrain cellthree-dimensional modeling

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英文摘要
Certain amino acids in the Fr98 mouse retroviral envelope were found o be essential for the brain disease induced by this virus. These amino acids were located in several separated locations in the sequence when viewed as a linear structure. In contrast when assembled as a three dimensional model based on the crystal structure of a closely related mouse retrovirus, these amino acids were located in two distinct groups. These results supported the idea that two separate but cooperative mechanisms of pathogenesis are induced by infection with this retrovirus.
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