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Nanostructured Hydrogel Films for Encapsulation & Release

用于封装的纳米结构水凝胶薄膜

基本信息

批准号：
EP/E029914/1
负责人：
Karen Edler
金额：
$ 38.99万
依托单位：
University of Bath
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2007
资助国家：
英国
起止时间：
2007 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FE029914%2F1
关键词：
Nanostructured Hydrogel Films Encapsulation Release

项目摘要

We have recently discovered a new method of making solid nanostructured films of water soluble polymers with surfactants. These membranes form spontaneously at the surface of aqueous solutions of the two components, and contain highly ordered arrays of micelles surrounded and bound together by the polymer. The films are robust, can be easily lifted from the interface where they form, and will grow over an arbitrarily large area, the size of the container where they are prepared. Our preliminary experiments have shown that it is possible to incorporate hydrophobic material within the micelle array inside the films. The ability to encapsulate other molecules in these films raises the possibility of using them for sustained release applications to deliver eg drugs, flavours, pesticides etc. In this proposal we will work to develop polymer-surfactant membrane-forming systems to optimise nanostructure formation and encapsulation properties and to map the relationship between polymer and surfactant properties and those of the resulting membrane. This new method provides a simple, cheap and straightforward method to creating large areas of free-standing polymer membranes with encapsulated material and in this proposal we will particularly target formation of the membranes from biocompatible polymers towards potential drug release applications.

我们最近发现了一种用表面活性剂制备水溶性聚合物固体纳米结构膜的新方法。这些膜在两种组分的水溶液的表面自发形成，并且包含由聚合物包围并结合在一起的高度有序的胶束阵列。这些膜是坚固的，可以很容易地从它们形成的界面上提起，并且将在任意大的面积上生长，所述面积是制备它们的容器的尺寸。我们的初步实验表明，它是可能的，将疏水材料内的胶束阵列内的膜。在这些膜中封装其他分子的能力提高了使用它们的可能性，用于缓释应用，以提供例如药物，香料，农药等。在本提案中，我们将致力于开发聚合物-表面活性剂膜形成系统，以优化纳米结构的形成和封装性能，并绘制聚合物和表面活性剂的性能和所得膜之间的关系。这种新方法提供了一种简单、廉价和直接的方法来产生大面积的具有包封材料的自支撑聚合物膜，并且在该提议中，我们将特别针对从生物相容性聚合物形成膜以实现潜在的药物释放应用。