Antiretroviral Therapy for HIV-2 Infection in Senegal
塞内加尔针对 HIV-2 感染的抗逆转录病毒治疗
基本信息
- 批准号:7367162
- 负责人:
- 金额:$ 62.92万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2005
- 资助国家:美国
- 起止时间:2005-06-07 至 2010-02-28
- 项目状态:已结题
- 来源:
- 关键词:Acquired Immunodeficiency SyndromeAdverse effectsAnti-Retroviral AgentsArtsBloodCD3 AntigensCD4 Positive T LymphocytesCD4/CD8 ratio procedureCD8B1 geneCell CountCessation of lifeCharacteristicsClinicalControl GroupsCultured CellsDrug resistanceDrug-sensitiveEventEvolutionFailureGaggingGoalsGrowthHIV-1HIV-1 drug resistanceHIV-2ImmunologicsIndividualInfectionMediatingMethodsMutationNNRTI-resistanceNatural HistoryOutcomePatternPeripheral Blood Mononuclear CellPhenotypePhylogenetic AnalysisPlasmaPlayPopulationProtease GeneRNARNA-Directed DNA PolymeraseRateResistanceResourcesRoleSenegalSexual TransmissionStagingSymptomsT-Lymphocyte SubsetsTestingTimeTreatment ProtocolsVertical Disease TransmissionViralViral Load resultVirusantiretroviral therapycohortdrug resistant virusenv Genesfitnessmortalityprogramsprospectiveresponsetrendviral DNA
项目摘要
DESCRIPTION (provided by applicant): The overarching goals of this proposal are to further our understanding of the effect of potent antiretroviral therapy (ART) on Human Immunodeficiency Virus Type 2 (HIV-2) infection. HIV-2 is generally less pathogenic than HIV-1. Compared to HIV-1, HIV-2 infection is characterized by a much longer asymptomatic stage, lower plasma viral loads, slower decline in CD4+ T cell count, decreased mortality rate due to AIDS, lower rates of mother to child transmission, and lower rates of sexual transmission. Nonetheless, a significant proportion of HIV-2 infected individuals eventually progress to AIDS. Antiretrov'iral therapy is becoming increasingly available in resource-limited settings. In Senegal where both HIV-1 and HIV-2 are found, a national program of providing antiretroviral treatment (ART) for those with AIDS, CD4+ T cell counts less than 200/mm3, or CD4+ T cell counts less than 350/mm3 and clinical symptoms has been established. However, the effects of ART on outcome, immunologic response, viral load, dynamics and evolution, HIV-2 drug resistance and fitness in HIV-2 infected individuals are largely unknown. Our longstanding longitudinal cohort of HIV-2 infected subjects from Dakar, Senegal provides a unique opportunity to study the role ART plays in suppressing HIV-2 infection. The Specific Aims of this proposal are: AIM 1: To determine the clinical, virologic and immunologic outcomes associated with antiretroviral therapy (ART) in a longitudinal prospective HIV-2 infected Senegalese cohort. AIM 2: To assess role of drug resistance in viruses that emerge in HIV-2 infected subjects with virologic failure and to determine if there are qualitative and quantitative differences the drug resistant viruses that emerge between HIV-2 and HIV-1.
描述(由申请人提供):本提案的总体目标是进一步了解强效抗逆转录病毒疗法(ART)对人类免疫缺陷病毒2型(HIV-2)感染的影响。HIV-2的致病性通常低于HIV-1。与HIV-1相比,HIV-2感染的特点是无症状期更长,血浆病毒载量更低,CD 4 + T细胞计数下降较慢,艾滋病死亡率降低,母婴传播率降低,性传播率降低。尽管如此,仍有相当比例的HIV-2感染者最终发展为艾滋病。抗逆转录病毒疗法在资源有限的环境中变得越来越可用。在发现HIV-1和HIV-2的塞内加尔,已经制定了一项国家方案,为那些患有艾滋病、CD 4 + T细胞计数低于200/mm 3或CD 4 + T细胞计数低于350/mm 3并有临床症状的人提供抗逆转录病毒治疗。 然而,ART对HIV-2感染者的结局、免疫应答、病毒载量、动力学和进化、HIV-2耐药性和适应性的影响在很大程度上是未知的。我们来自塞内加尔达喀尔的HIV-2感染受试者的长期纵向队列提供了一个独特的机会来研究ART在抑制HIV-2感染中的作用。该提案的具体目标是:目标1:确定在纵向前瞻性HIV-2感染的塞内加尔队列中与抗逆转录病毒治疗(ART)相关的临床、病毒学和免疫学结局。目标2:评估耐药性在病毒学失败的HIV-2感染受试者中出现的病毒中的作用,并确定HIV-2和HIV-1之间出现的耐药性病毒是否存在定性和定量差异。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Geoffrey Scott Gottlieb其他文献
Infection à VIH-2 au Sénégal: échecs virologiques et résistances aux antirétroviraux (ARV)
塞内加尔 VIH-2 感染:病毒学和抗逆转录病毒 (ARV) 抵抗
- DOI:
- 发表时间:
2019 - 期刊:
- 影响因子:0
- 作者:
Selly Ba;N. Dia;S. E. Hawes;L. Déguénonvo;F. Sall;C. Ndour;Khadim Faye;F. Traoré;Macoumba Touré;M. Sy;Dana Noelle Raugi;N. Kiviat;Robert A. Smith;M. Seydi;P. Sow;Geoffrey Scott Gottlieb - 通讯作者:
Geoffrey Scott Gottlieb
Geoffrey Scott Gottlieb的其他文献
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{{ truncateString('Geoffrey Scott Gottlieb', 18)}}的其他基金
Improving Diagnosis, Treatment & Detection of Drug Resistance in HIV-2 Infection
改善诊断、治疗
- 批准号:
10189489 - 财政年份:2015
- 资助金额:
$ 62.92万 - 项目类别:
Improving Diagnosis, Treatment & Detection of Drug Resistance in HIV-2 Infection
改善诊断、治疗
- 批准号:
10078744 - 财政年份:2015
- 资助金额:
$ 62.92万 - 项目类别:
Improving Diagnosis, Treatment & Detection of Drug Resistance in HIV-2 Infection
改善诊断、治疗
- 批准号:
9089930 - 财政年份:2015
- 资助金额:
$ 62.92万 - 项目类别:
Improving Diagnosis, Treatment & Detection of Drug Resistance in HIV-2 Infection
改善诊断、治疗
- 批准号:
10398906 - 财政年份:2015
- 资助金额:
$ 62.92万 - 项目类别:
Improving Diagnosis, Treatment & Detection of Drug Resistance in HIV-2 Infection
改善诊断、治疗
- 批准号:
9274145 - 财政年份:2015
- 资助金额:
$ 62.92万 - 项目类别:
Improving Diagnosis, Treatment & Detection of Drug Resistance in HIV-2 Infection
改善诊断、治疗
- 批准号:
8991978 - 财政年份:2015
- 资助金额:
$ 62.92万 - 项目类别:
Improving Diagnosis, Treatment & Detection of Drug Resistance in HIV-2 Infection
改善诊断、治疗
- 批准号:
10652277 - 财政年份:2015
- 资助金额:
$ 62.92万 - 项目类别:
Antiretroviral Therapy for HIV-2 Infection in Senegal
塞内加尔针对 HIV-2 感染的抗逆转录病毒治疗
- 批准号:
7836630 - 财政年份:2005
- 资助金额:
$ 62.92万 - 项目类别:
Antiretroviral Therapy for HIV-2 Infection in Senegal
塞内加尔针对 HIV-2 感染的抗逆转录病毒治疗
- 批准号:
8469814 - 财政年份:2005
- 资助金额:
$ 62.92万 - 项目类别:
Antiretroviral Therapy for HIV-2 Infection in Senegal
塞内加尔针对 HIV-2 感染的抗逆转录病毒治疗
- 批准号:
8660589 - 财政年份:2005
- 资助金额:
$ 62.92万 - 项目类别:
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