Host-pathogen interactions in clostridial myonecrosis

梭菌性肌坏死中宿主与病原体的相互作用

• 批准号: nhmrc : 1005991
• 负责人: Dr Milena Awad
• 金额: $ 38.51万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/host-pathogen-interactions-clostridial-myonecrosis/109132
• 关键词: Host; pathogen; interactions; clostridial; myonecrosis

We will analyse the interaction between the bacteria that cause gas gangrene, and the infected host, from both a host and pathogen perspective. We will examine how the host’s response to infection can be modulated to decrease the severity of disease and we will identify the biochemical processes that are essential for bacterial growth in the host, a necessary prerequisite for disease. Outcomes will be a better understanding of the mechanisms of disease causation and improved disease control.

我们将从宿主和病原体的角度分析引起气性坏疽的细菌与受感染宿主之间的相互作用。我们将研究如何调节宿主对感染的反应以降低疾病的严重程度，我们将确定宿主中细菌生长所必需的生化过程，这是疾病的必要先决条件。结果将是更好地了解疾病的病因机制和改善疾病控制。