Improving Effectiveness and Accuracy of Radiation Therapy

提高放射治疗的有效性和准确性

基本信息

项目摘要

DESCRIPTION (provided by applicant): Introduction: Effectiveness of radiation therapy can be improved through increased accuracy in radiotherapy calculations. The proposed research will focus on two types of cancer, prostate and lung. The proposed prostate cancer research is an extension of earlier work while the lung cancer research is a new area of interest. Background: Treatment for prostate cancer is successful in most cases. Although 1 in 8 men will be diagnosed with prostate cancer, only 1 in 34 will die from prostate cancer (American Cancer Society). Research proposed in Specific Aims 1 and 2 focuses on decreasing adverse radiation side-effects by increasing the understanding of dose distributions and side effects from Intensity Modulated Radiation therapy (IMRT) for prostate cancer. The goal of this project is to provide Radiation Oncologists the necessary information to select the most appropriate beam energy for individual patients. Lung cancer is the leading cause of cancer death in the United States, approximately 6 out of 10 people with lung cancer die within 1 year of being diagnosed (American Cancer Society). Improving the therapeutic gains in lung cancer is imperative. Specific Aims 3 and 4 focus on improving the accuracy of dose calculations in lung cancer radiation therapy with the long term goal of understanding how much radiation dose is necessary to increase cure rates. Hypothesis: Increased accuracy in radiotherapy dose calculations can reduce adverse side effects from prostate cancer radiotherapy and can increase the therapeutic gain for lung cancer radiotherapy. Specific Aims: The following research aims will be addressed: (1) Perform skin dose measurements to evaluate skin reactions for prostate cancer patients treated with 6MV beam energy for IMRT; (2) Perform Monte Carlo calculations (in phantom) of dose to peripheral organs from IMRT, expandable to individual patient calculations; three years of protected time to facilitate her transition to an established cancer researcher. Her research plan is based on her previous work in improving the quantification of dosage effects for intensity-modulated radiotherapy (IMRT). The previous submission was primarily critiqued for lack of a full breadth of training activities and for brevity of research methods including a lack of statistical analyses methods and justification.
描述(由申请人提供):引言:放射治疗的有效性可以通过提高放射治疗计算的准确性来提高。拟议的研究将集中在两种类型的癌症,前列腺癌和肺癌。拟议中的前列腺癌研究是早期工作的延伸,而肺癌研究是一个新的感兴趣的领域。背景:前列腺癌的治疗在大多数情况下是成功的。虽然八分之一的男性会被诊断出患有前列腺癌,但只有三十四分之一的男性会死于前列腺癌(美国癌症协会)。具体目标1和2中提出的研究重点是通过增加对前列腺癌调强放射治疗(IMRT)剂量分布和副作用的理解来减少不良辐射副作用。该项目的目标是为放射肿瘤学家提供必要的信息,以选择最合适的射束能量为个别患者。在美国,肺癌是癌症死亡的主要原因,大约10个肺癌患者中有6个在诊断后1年内死亡(美国癌症协会)。提高肺癌的治疗效果势在必行。具体目标3和4侧重于提高肺癌放射治疗中剂量计算的准确性,长期目标是了解增加治愈率所需的辐射剂量。 假设:提高放疗剂量计算的准确性可以减少前列腺癌放疗的不良副作用,并可以增加肺癌放疗的治疗增益。具体目标:将解决以下研究目标:(1)进行皮肤剂量测量,以评估接受调强放射治疗的6 MV射束能量治疗的前列腺癌患者的皮肤反应;(2)进行蒙特卡罗计算(体模),计算调强放射治疗对外周器官的剂量,可扩展到个体患者计算;三年的保护时间,以促进她转变为一名成熟的癌症研究人员。她的研究计划是基于她以前的工作,在改善定量的剂量效应调强放疗(IMRT)。先前提交的报告受到的批评主要是缺乏培训活动的全面性和研究方法的简洁性,包括缺乏统计分析方法和理由。

项目成果

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Rebecca Maureen Howell其他文献

Rebecca Maureen Howell的其他文献

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{{ truncateString('Rebecca Maureen Howell', 18)}}的其他基金

Personalized Risk Prediction to Reduce Cardiovascular Disease in Childhood Cancer Survivors
个性化风险预测可减少儿童癌症幸存者的心血管疾病
  • 批准号:
    10458172
  • 财政年份:
    2022
  • 资助金额:
    $ 13.37万
  • 项目类别:
Personalized Risk Prediction to Reduce Cardiovascular Disease in Childhood Cancer Survivors
个性化风险预测可减少儿童癌症幸存者的心血管疾病
  • 批准号:
    10666533
  • 财政年份:
    2022
  • 资助金额:
    $ 13.37万
  • 项目类别:
Improving Effectiveness and Accuracy of Radiation Therapy
提高放射治疗的有效性和准确性
  • 批准号:
    7498507
  • 财政年份:
    2007
  • 资助金额:
    $ 13.37万
  • 项目类别:
Improving Effectiveness and Accuracy of Radiation Therapy
提高放射治疗的有效性和准确性
  • 批准号:
    7682100
  • 财政年份:
    2007
  • 资助金额:
    $ 13.37万
  • 项目类别:

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